5fyw_ABMORU : 3D-footprint complex

structure name	TRANSCRIPTION INITIATION COMPLEX STRUCTURES ELUCIDATE DNA OPENING (OC)
reference	Dienemann et al. Nature 533 353 2016
source	SACCHAROMYCES CEREVISIAE
experiment	X-ray (resolution=4.35, R-factor=?)
structural superfamily	Cyclin-like;Zinc beta-ribbon;Rap30/74 interaction domains;"Winged helix" DNA-binding domain;Transcription factor IIA TFIIA, beta-barrel domain;Transcription factor IIA TFIIA, alpha-helical domain;
reference complex	5oqj_M 5oqj_R 5oqj_U 7ml0_W
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 5fyw_A interface=812, gqqyssaplrtvkevqfglfspeevraisvakirfpetmdetqtrakigglndprlgsidrnlkcqtcqegmnecpghfghidlakpvfhvgfiakikkvcecvcmhcgkllldehnelmrqalaikdskkrfaaiwtlcktkmvcetdvpsrggcgntqptirkdglklvgswkkpelrvlsteeilnifkhisvkdftslgfnevfsrpewmiltclpvppppvrpsisfnesqrgeddltfkladilkanisletlehngaphhaieeaesllqfhvatymdndiagqpqalqksgrpvksirarlkgkegrirgnlmgkrvdfsartvisgdpnleldqvgvpksiaktltypevvtpynidrltqlvrngpnehpgakyvirdsgdridlryskragdiqlqygwkverhimdndpvlfnrqpslhkmsmmahrvkvipystfrlnlsvtspynadfdgdemnlhvpqseetraelsqlcavplqivspqsnkpcmgivqdtlcgirkltlrdtfieldqvlnmlywvpdwdgviptpaiikpkplwsgkqilsvaipngihlqrfdegttllspkdngmliidgqiifgvvekktvgssngglihvvtrekgpqvcaklfgniqkvvnfwllhngfstgigdtiadgptmreitetiaeakkkvldvtkeaqanlltakhgmtlresfednvvrflneardkagrlaevnlkdlnnvkqmvmagskgsfiniaqmsacvgqqsvegkriafgfvdrtlphfskddyspeskgfvensylrgltpqefffhamggreglidtavktAetgyiqrrlvkaledimvhydnttrnslgnviqfiygedgmdaahiekqsldtiggsdaafekryrvdllntdhtldpsllesgseilgdlklqvlldeeykqlvkdrkflrevfvdgeanwplpvnirriiqnaqqtfhidhtkpsdltikdivlgvkdlqenllvlrgkneiiqnaqrdavtlfccllrsrlatrrvlqeyrltkqafdwvlsnieaqflrsvvhpgemvgvlaaqsigepatqmkvtsgvprlkeilnvaknmktpsltvylepghaadqeqaklirsaiehttlksvtiaseiyydpdprstvipedeeiiqlhfsqqspwllrleldraamndkdltmgqvgerikqtfkndlfviwsedndekliircrvvaeedhmlkkientmlenitlrgveniervvmmkydrkvpsptgeyvkepewvletdgvnlsevmtvpgidptriytnsfidimevlgieagraalykevynviasdgsyvnyrhmallvdvmttqggltsvtrhgfnrsntgalmrcsfeetveilfeagasaelddcrgvsenvilgqmapigtgafdvmideeslvk > 5fyw_B interface=479, desapitaedswavisaffrekglvsqqldsfnqfvdytlqdiicedstlileqlaqisrkyeisfgkiyvtkpmvnesdgvthalypqearlrnltyssglfvdvkkrtyelkyelaeesegkvfigrlpimlrskncylseatesdlyklkecpfdmggyfiingsekvliaqersagnivqvfkkaapspishvaeirsalekgsrfistlqvklygregssartikatlpyikqdipiviifralgiipdgeilehicydvndwqmlemlkpcvedgfviqdretaldfigrrgtalgikkekriqyakdilqkeflphitqlegfesrkafflgyminrlllcaldrkdqddrdhfgkkrldlagpllaqlfktlfkkltkdifrymqrtveeahdfnmklainaktitsglkyalatgnwgssragvsqvlnrytysstlshlrrtntpiakprqlhnthwglvcpaetpegQacglvknlslmscisvgtdpmpiitflsewgmepledyvphqspdatrvfvngvwhgvhrnparlmetlrtlrrkgdinpevsmirdirekelkiftdagrvyrplfiveddeslghkelkvrkghiaklmateyqddveeytwssllneglveyidaeeeesiliamqpedlepaevdpakrirvshhattfthceihpsmilgvaasiipfpdhnqsprntyqsamgkqamgvfltnynvrmdtmanilyypqkplgttrameylkfrelpagqnaivaiacysgynqedsmimnqssidrglfrslffrsymdqekkygmsitetfekpqrtntlrmkhgtydkldddgliapgvrvsgedviigkttpispdeeelgqrtayhskrdastplrstengivdqvlvttnqdglkfvkvrvrttkipqigdkfasrhgqkgtigityrredmpftaegivpdliinphaipsrmtvahliecllskvaalsgnegdaspftditvegiskllrehgyqsrgfevmynghtgkklmaqiffgptyyqrlrhmvddkiharargpmqvltrqpvegrsrdgglrfgemerdcmiahgaasflkerlmeasdafrvhicgicglmtviaklnhnqfeckgcdnkidiyqihipyaakllfqelmamnitprlytdrsrd > 5fyw_M interface=121, pnlnivltcpeckvyppkiverfsegdvvcalcglvlsdklvdnevqaafakitmlcdaaelpkivkdcakeayklchdektlkgksmesimaasiligcrraevartfkeiqslihvktKefgktlnimknilrgksqnltyiprfcshlglpmqvttsaeytakkckeikeiagkspitiavvsiylnillfqipitaakvgqtlqvtegtiksgykilyehrdklvdp > 5fyw_O interface=9,11,39,54,56,62,64,99,101,130,131,145,153,155, sgivptlqNiVatvtlgcrldlktvalharnaeynpkrFaavimrirepkttaLiFasgkmVvTgakseddsklasrkyariiqkigfaakftdfkiqNiVgscdvkfpirleglafshgtfssyepelFPgliyrmvkpkivlLifvsgkiVlTgakqreeiyqafeaiypvlsefrkm > 5fyw_R interface=162, dldlersnrqvwlvrlpmflaekwrlgkirinkskitlllnepheydleltkkvveneyvfteqtipkktaivgtvchecqvmpyhkiveqrrnivkerittldetvgvtmshtgmsmrsdnsnflkvmpkkeildylfklfdeydywslkglkertrqpeAhlkecldkvatlvkkgpyafkytlrkeeerkatlgel > 5fyw_U interface= snaeasrvyeiivesvvnevredfenagideqtlqdlkniwqkkltenlmlclydkvtrtkarwkcslkdgvvtinrndytfqkaqveaewv
interface signature	A/Q/K/NVFLFVTNVFPLVT/A/

Estimated binding specificities ?

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# IC=7.099 IC/col=1.014 n_of_columns=7

specificity:

A |   0   0  96   0  54   0  54
C |   0   0   0   0  13   0  13
G |   0   0   0   0  16   0  16
T |  96  96   0  96  13  96  13

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updated Sat Dec 14 02:12:43 2024