interface graph thumbnail
legend  pdf

structure nameSTRUCTURE OF A HUMAN TOPOISOMERASE IIBETA FRAGMENT IN COMPLEX WITH DNA AND E7873R
(DNA topoisomerase 2-beta)
referenceWang et al. 'Nucleic 45 10861 2017
sourceHomo sapiens
experimentX-ray (resolution=2.74, R-factor=0.215)
structural superfamilyType II DNA topoisomerase;
sequence familyDNA gyrase/topoisomerase IV, subunit A;
multimeric complexes4g0u_AB 4g0v_AB 4g0w_AB
reference complex3qx3_B
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureKDQAEIA

Estimated binding specificities ?

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# IC=2.968 IC/col=0.594 n_of_columns=5 specificity:   
A |  13  10  24   1   1
C |  11  45  24  94   0
G |  60  26  24   1  95
T |  12  15  24   0   0
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updated Mon Dec 18 12:51:36 2023