5i2d_CDFGH : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF T. THERMOPHILUS TTHB099 CLASS II TRANSCRIPTION ACTIVATION COMPLEX: TAP-RPO
reference	Ebright et al. Science 352 1330 2016
experiment	X-ray (resolution=4.41, R-factor=?)
structural superfamily	cAMP-binding domain-like;"Winged helix" DNA-binding domain;
reference complex	5i2d_R
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 5i2d_C interface=127,135,160,164,180,236,240,249,253,259,318,319,324,351,381,387,411,414,419,420, meikrfgrireviplpplteiqvesyrralqadvppekrenvgiqaafretfpieelvldfleyrlgeppfpqdecrekdltyqaplyarlqlihkdtglikedevflghiplmtedgsfiingadRvivsqihRspgvyftpdparpgryiasiiplpKrgpWidlevepngvvsmkvNkrkfplvlllrvlgydqetlarelgaygelvqglmdesvfamrpeealirlftllRpgdPpkrdkavaYvygLiadprRydlgeagrykaeeklgirlsgrtlarfedgefkdevflptlrylfaltagvpghevddIDhlgnRrirtvgelmtdqfrvglarlargvreRmlmgsedsltpaklvnsrpleaaireffsRsqlsqFkdetnplsslrhkrrisalgpggLtrEragfDVrdvhrthygricpvetpeganiglitslaayarvdelgfirtpyrrvvggvvtdevvymtateedrytiaqantplegnriaaervvarrkgepvivspeevefmdvspkqvfsvntnlipflehddanralmgsnmqtqavpliraqapvvmtgleervvrdslaalyaeedgevakvdgnrivvryedgrlveyplrrfyrsnqgtaldqrprvvvgqrvrkgdlladgpasengflalgqnvlvaimpfdgynfedaiviseellkrdfytsihieryeieardtklgperitrdiphlseaalrdldeegvvrigaevkpgdilvgrtsfkgeseptpeerllrsifgekardvkdtslrvppgeggivvrtvrlrrgdpgvelkpgvrevvrvyvaqkrklqvgdklanrhgnkgvvakilpvedmphlpdgtpvdvilnplgvpsrmnlgqilethlglagyflgqryispifdgakepeikellaqafevyfgkrkgegfgvdkrevevlrraeklglvtpgktpeeqlkelflqgkvvlydgrtgepiegpivvgqmfimklyhmvedkmharstgpyslitqqplggkaqfggqrfgemevwaleaygaahtlqemltlksddiegrnaayeaiikgedvpepsvpesfrvlvkelqalaldvqtldekdnpvdifeglask > 5i2d_D interface=580,581,963,964, kevrkvrialaspekirswsygevekpetinyrtlkperdglfderifgpikdyecacgkykrqrfegkvcercgvevtksivrryrmghielatpaahiwfvkdvpskigtlldlsateleqvlyfskyivldpkgailngvpvekrqlltdeeyrelrygkqetyplppgvdalvkdgeevvkgqelapgvvsrldgvalyrfprrvrveyvtepkdyrvqphmnvvvpegarveagdkivaaidpeeeviaeaegvvhlhepasilvvkarvypfeddvevstgdrvapgdvladggkvksdvygrvevdlvrnvvrvvesydidarmgaeaiqqllkeldlealekelleemkhpsrarrakarkrlevvrafldsgnrpewmileavpvlppdlrpmvqvdggrfatsdlndlyrrlinrnnrlkkllaqgapeiiirnekrmlqeavdalldngrrgapvtnpgsdrplrsltdilsgkqgrfrqnllgkrvdysgrsvivvgpqlklhqcglpkrmalelfkpfllkkmeekgiapnvkaarrmlerqrdikdevwdaleevihgkvvllnrAPtlhrlgiqafqpvlvegqsiqlhplvceafnadfdgdqmavhvplssfaqaeariqmlsahnllspasgeplakpsrdiilglyyitqvrkekkgaglefatpeealaahergevalnapikvagretsvgrlkyvfanpdeallavahgivdlqdvvtvrymgkrletspgrilfarivaeavedekvaweliqldvpqeknslkdlvyqaflrlgmektarlldalkyygftfsttsgitigiddavipeekkqyleeadrkllqieqayemgfltdrerydqilqlwtettekvtqavfknfeenypfnplyvmaqsgargnpqqirqlcglrglmqkpsgetfevpvrssfregltvleyfisshgarkggadtalrTAdsgyltrklvdvtheivvreadcgttnyisvplfqpdevtrslrlrkradieaglygrvlarevevlgvrleegrylsmddvhllikaaeageiqevpvrspltcqtrygvcqkcygydlsmarpvsigeavgivaaqsigepgtqltitqglprvielfearrpkakaviseidgvvrieeteeklsvfvesegfskeyklpkearllvkdgdyveagqpltrgaidphqlleakgpeaverylveeiqkvyraqgvklhdkhieivvrqmmkyvevtdpgdsrllegqvlekwdvealnerliaegktpvawkpllmgvtksalstkswlsaasfqntthvlteaaiagkkdeliglkenvilgrlipagtgsdfvrftqvvdqktlkaieearkea > 5i2d_F interface=2,4,5,8,11,16,22,114,116,117,150,151,154,156,159,160,161,163,164,165,167,168,171,179,185,186,189,191,192,195,199,236,238,242,244,252,306,317,318,321, sDpVRqyLheIgqvpLltleeEvelarkveegmeaikklseitgldpdlirevvrakilgsarvrhipglketldpktveeidqklkslpkehkrylhiaregeaarqhlieaNlRLvvsiakkytgrglsfldliqegnqgliravekFEykRrFkfSTYaTWWiRQaiNraiadqaRtiripVHmvEtINklSrtaRqlqqelgreptyeeiaeamgpgwdakrveetlkiaqEpVsleTpIgdekdsfYgdfipdehlpspvdaatqsllseelekalsklsereamvlklrkglidgrehtLeevgaffgvtREriRqienkalrklkyhesrtrklrdfld > 5i2d_G interface=152,153,154,155,157,158, mkrfarketiylrgeeartlyrleeglvrvvellpdgrlitlrhvlpgdyfgeealegkayrytaeamteavvqglepramdhealhrvarnlarqmrrvqayeahlqtgelrariaryllfladtplsardrqgiyvtvsheeiadatasIRESvSKvladlrregliatayrrvylldlaalereagsaleaa > 5i2d_H interface=152,153,154,155,158, mkrfarketiylrgeeartlyrleeglvrvvellpdgrlitlrhvlpgdyfgeealegkayrytaeamteavvqglepramdhealhrvarnlarqmrrvqayeahlqtgelrariaryllfladtplsardrqgiyvtvsheeiadatasIRESvsKvladlrregliatayrrvylldlaalereagsaleaa
interface signature	RRKWNRPYLRIDRRRFLEDV/APTA/DVRLILENRLFERFSTYTWWRQNRVHEINSREVTIYLRER/IRESSK/IRESK

Estimated binding specificities ?

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# IC=38.030 IC/col=0.731 n_of_columns=52

specificity:

A |  96   0   0   0   0  78   0   0   0   0  96  96   0  96  96   0  24  24  24  96  24  24  24  24  24  24  24  24  24  24  24  24  24   0  84   3   0   0   0   0  96  15  24  24  24  24   6   6   0  78   0  96
C |   0   0   0  96   0   6   0   0   0   0   0   0   0   0   0  96  24  24  24   0  24  24  24  24  24  24  24  24  24  24  24  24  24   0   3  87   0   0   0   0   0  15  24  24  24  24  78   6  96   6  96   0
G |   0  96   0   0  96   6  96  96  96   0   0   0   0   0   0   0  24  24  24   0  24  24  24  24  24  24  24  24  24  24  24  24  24  96   6   3   0  96   0  96   0  51  24  24  24  24   6   6   0   6   0   0
T |   0   0  96   0   0   6   0   0   0  96   0   0  96   0   0   0  24  24  24   0  24  24  24  24  24  24  24  24  24  24  24  24  24   0   3   3  96   0  96   0   0  15  24  24  24  24   6  78   0   6   0   0

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updated Tue Sep 10 04:44:33 2024