5i2d_NOQRS : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF T. THERMOPHILUS TTHB099 CLASS II TRANSCRIPTION ACTIVATION COMPLEX: TAP-RPO
reference	Ebright et al. Science 352 1330 2016
experiment	X-ray (resolution=4.41, R-factor=?)
structural superfamily	cAMP-binding domain-like;"Winged helix" DNA-binding domain;
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 5i2d_N interface=127,135,159,160,164,180,236,240,249,253,259,318,319,324,351,381,387,411,414,415,419,420,440, meikrfgrireviplpplteiqvesyrralqadvppekrenvgiqaafretfpieelvldfleyrlgeppfpqdecrekdltyqaplyarlqlihkdtglikedevflghiplmtedgsfiingadRvivsqihRspgvyftpdparpgryiasiiplPKrgpWidlevepngvvsmkvNkrkfplvlllrvlgydqetlarelgaygelvqglmdesvfamrpeealirlftllRpgdPpkrdkavaYvygLiadprRydlgeagrykaeeklgirlsgrtlarfedgefkdevflptlrylfaltagvpghevddIDhlgnRrirtvgelmtdqfrvglarlargvreRmlmgsedsltpaklvnsrpleaaireffsRsqlsqFkdetnplsslrhkrrisalgpggLtrERagfDVrdvhrthygricpvetpegAniglitslaayarvdelgfirtpyrrvvggvvtdevvymtateedrytiaqantplegnriaaervvarrkgepvivspeevefmdvspkqvfsvntnlipflehddanralmgsnmqtqavpliraqapvvmtgleervvrdslaalyaeedgevakvdgnrivvryedgrlveyplrrfyrsnqgtaldqrprvvvgqrvrkgdlladgpasengflalgqnvlvaimpfdgynfedaiviseellkrdfytsihieryeieardtklgperitrdiphlseaalrdldeegvvrigaevkpgdilvgrtsfkgeseptpeerllrsifgekardvkdtslrvppgeggivvrtvrlrrgdpgvelkpgvrevvrvyvaqkrklqvgdklanrhgnkgvvakilpvedmphlpdgtpvdvilnplgvpsrmnlgqilethlglagyflgqryispifdgakepeikellaqafevyfgkrkgegfgvdkrevevlrraeklglvtpgktpeeqlkelflqgkvvlydgrtgepiegpivvgqmfimklyhmvedkmharstgpyslitqqplggkaqfggqrfgemevwaleaygaahtlqemltlksddiegrnaayeaiikgedvpepsvpesfrvlvkelqalaldvqtldekdnpvdifeglask > 5i2d_O interface=580,581,963,964, kevrkvrialaspekirswsygevekpetinyrtlkperdglfderifgpikdyecacgkykrqrfegkvcercgvevtksivrryrmghielatpaahiwfvkdvpskigtlldlsateleqvlyfskyivldpkgailngvpvekrqlltdeeyrelrygkqetyplppgvdalvkdgeevvkgqelapgvvsrldgvalyrfprrvrveyvtepkdyrvqphmnvvvpegarveagdkivaaidpeeeviaeaegvvhlhepasilvvkarvypfeddvevstgdrvapgdvladggkvksdvygrvevdlvrnvvrvvesydidarmgaeaiqqllkeldlealekelleemkhpsrarrakarkrlevvrafldsgnrpewmileavpvlppdlrpmvqvdggrfatsdlndlyrrlinrnnrlkkllaqgapeiiirnekrmlqeavdalldngrrgapvtnpgsdrplrsltdilsgkqgrfrqnllgkrvdysgrsvivvgpqlklhqcglpkrmalelfkpfllkkmeekgiapnvkaarrmlerqrdikdevwdaleevihgkvvllnrAPtlhrlgiqafqpvlvegqsiqlhplvceafnadfdgdqmavhvplssfaqaeariqmlsahnllspasgeplakpsrdiilglyyitqvrkekkgaglefatpeealaahergevalnapikvagretsvgrlkyvfanpdeallavahgivdlqdvvtvrymgkrletspgrilfarivaeavedekvaweliqldvpqeknslkdlvyqaflrlgmektarlldalkyygftfsttsgitigiddavipeekkqyleeadrkllqieqayemgfltdrerydqilqlwtettekvtqavfknfeenypfnplyvmaqsgargnpqqirqlcglrglmqkpsgetfevpvrssfregltvleyfisshgarkggadtalrTAdsgyltrklvdvtheivvreadcgttnyisvplfqpdevtrslrlrkradieaglygrvlarevevlgvrleegrylsmddvhllikaaeageiqevpvrspltcqtrygvcqkcygydlsmarpvsigeavgivaaqsigepgtqltitqglprvielfearrpkakaviseidgvvrieeteeklsvfvesegfskeyklpkearllvkdgdyveagqpltrgaidphqlleakgpeaverylveeiqkvyraqgvklhdkhieivvrqmmkyvevtdpgdsrllegqvlekwdvealnerliaegktpvawkpllmgvtksalstkswlsaasfqntthvlteaaiagkkdeliglkenvilgrlipagtgsdfvrftqvvdqktlkaieearkea > 5i2d_Q interface=2,4,5,8,9,16,22,114,116,117,150,151,154,156,157,159,160,161,163,164,167,168,171,179,185,186,189,191,192,195,196,199,236,238,242,244,252,317,318,321, sDpVRqyLHeigqvpLltleeEvelarkveegmeaikklseitgldpdlirevvrakilgsarvrhipglketldpktveeidqklkslpkehkrylhiaregeaarqhlieaNlRLvvsiakkytgrglsfldliqegnqgliravekFEykRrFKfSTYaTWwiRQaiNraiadqaRtiripVHmvEtINklSRtaRqlqqelgreptyeeiaeamgpgwdakrveetlkiaqEpVsleTpIgdekdsfYgdfipdehlpspvdaatqsllseelekalsklsereamvlklrkglidgrehtleevgaffgvtREriRqienkalrklkyhesrtrklrdfld > 5i2d_R interface=152,153,154,155,157,158, mkrfarketiylrgeeartlyrleeglvrvvellpdgrlitlrhvlpgdyfgeealegkayrytaeamteavvqglepramdhealhrvarnlarqmrrvqayeahlqtgelrariaryllfladtplsardrqgiyvtvsheeiadatasIRESvSKvladlrregliatayrrvylldlaalereagsaleaa > 5i2d_S interface=152,153,154,158, mkrfarketiylrgeeartlyrleeglvrvvellpdgrlitlrhvlpgdyfgeealegkayrytaeamteavvqglepramdhealhrvarnlarqmrrvqayeahlqtgelrariaryllfladtplsardrqgiyvtvsheeiadatasIREsvsKvladlrregliatayrrvylldlaalereagsaleaa
interface signature	RRPKWNRPYLRIDRRRFLERDVA/APTA/DVRLHLENRLFERFKSTYTWRQNRVHEINSRREVTIYRER/IRESSK/IREK

Estimated binding specificities ?

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# IC=34.758 IC/col=0.668 n_of_columns=52

specificity:

A |  96   0   0   0   0  76   0   0   0   0  96  96   0  96  96   4  24  24  24  96  24  24  24  24  24  24  24  24  24  24  24  24  24   4  24   4   0   0   0   0  96  24  24  24  24  24  24   8   0  84   4  96
C |   0   0   0  96   0   4   0   0   0   0   0   0   0   0   0  84  24  24  24   0  24  24  24  24  24  24  24  24  24  24  24  24  24   4  24  84   0   0   0   0   0  24  24  24  24  24  24   8  96   4  84   0
G |   0  96   0   0  96   8  96  96  96   0   0   0   0   0   0   4  24  24  24   0  24  24  24  24  24  24  24  24  24  24  24  24  24  84  24   4   0  96   0  96   0  24  24  24  24  24  24   8   0   4   4   0
T |   0   0  96   0   0   8   0   0   0  96   0   0  96   0   0   4  24  24  24   0  24  24  24  24  24  24  24  24  24  24  24  24  24   4  24   4  96   0  96   0   0  24  24  24  24  24  24  72   0   4   4   0

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updated Tue Sep 10 04:48:34 2024