interface graph thumbnail
legend  pdf

structure nameCRYSTAL STRUCTURE OF SMAD4-MH1 BOUND TO THE GGCCG SITE.
(MH1 domain of human Smad4)
referenceKaczmarska et al. 'Nat 8 2070 2017
sourceHomo sapiens
experimentX-ray (resolution=3.03, R-factor=0.232)
structural superfamilySMAD MH1 domain;
sequence familyMH1 domain;
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureDRQK

Estimated binding specificities ?

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# IC=4.747 IC/col=0.678 n_of_columns=7 specificity:   
A |   6   6   0   6  24   6   6
C |  78   6   0  78  24  78   6
G |   6  78  96   6  24   6  78
T |   6   6   0   6  24   6   6
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updated Tue Dec 17 02:17:48 2024