5no6_N : 3D-footprint complex

structure name	TEAD4-HOXB13 COMPLEX BOUND TO DNA (TRANSCRIPTIONAL ENHANCER FACTOR TEF-3)
reference	Morgunova et al. 'To ? ? ?
source	HOMO SAPIENS
experiment	X-ray (resolution=2.88, R-factor=0.244)
structural superfamily	Homeodomain-like;
multimeric complexes	5no6_AN 5no6_BI
redundant complexes	5nnx_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 5no6_N interface=39,56,57,60,61,64,65, egvwspdieqsfqealaiyppcgrrkiilsdegkmygrNeliaryiklrtgktrtRKqvSShiQVlarrkare
interface signature	NRKSSQV

Estimated binding specificities ?

readout + contact

# IC=5.216 IC/col=0.869 n_of_columns=6

specificity:

A |   0   0  69  96   8  72
C |   0   0  11   0  11   8
G |  88  96   8   0   8   8
T |   8   0   8   0  69   8

scan!

Related DNA sequences reported in the literature ?

site	source	matches (E-value)
term: TEAD1
GGAATG	PubMed	5no6_N(5.14e-08), 5no6_AN(1.25e-07), 5no6_BI(1.90e-04), ... (total=4)
GGTATG	PubMed	5no6_N(8.29e-04), 5no6_AN(1.52e-03), 5nnx_A(1.91e-04)
CATTCCT	PubMed	5no6_N(2.37e-06), 5no6_AN(5.98e-06), 5no6_BI(1.79e-03), ... (total=4)

Dendrogram of similar interfaces ?

matrix format

  
  ------------NGRGKGSGSA--QAVC----   L                             +5no6_N    
                                                    +--------------1 
  --------------RGKGSGSA--QAVCRT--   L              !              +5gzb_A    
                                           +--------3 
  ----------------VTKGDC--RGTA----   L     !        !           +---1w0u_A    
                                         +-4        +-----------2 
  ------------------FTYA--QTNAATRG   L   ! !                    +---6ryd_F    
                                       --5 ! 
  NGFGRAKTYART----------IG--SG----   L   ! +------------------------3vw4_A    
                                         ! 
  --------------STVCKGDC--RG------   L   +-------------------------1w0t_A

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updated Sun Aug 3 09:39:33 2025