5t7x_B : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF HHV-4 EBNA1 DNA BINDING DOMAIN (PATIENT-DERIVED, NASOPHARYNGEAL CARCINOMA) BOUND TO DNA (Epstein-Barr nuclear antigen 1)
reference	Lieberman et al. Oncotarget 8 7248 2017
source	Human herpesvirus 4 (strain B95-8) / Human herpesvirus 4 (strain B95-8)
experiment	X-ray (resolution=2.35, R-factor=0.190)
structural superfamily	Viral DNA-binding domain;
sequence family	Epstein Barr virus nuclear antigen1, DNAbi;
multimeric complexes	5t7x_AB
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 5t7x_B interface=3,6,7,19,56,57,60,61,64, rkKggWFgkhrgqggsnpKfeniaeglrvllarshvertteegnwvagvfvyggsKTslYNlrRgialavpqcritplsrlpfgmapgpgpqpgplresivcyfmvflqthifaevlkdaikdlvmikpaptcnikvtvcsfddgvdlp
interface signature	KWFKKTYNR

Estimated binding specificities ?

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# IC=7.140 IC/col=1.020 n_of_columns=7

specificity:

A |  13  16   0  96   0   0   0
C |  13  54   0   0   0  96  96
G |  57  13   0   0   0   0   0
T |  13  13  96   0  96   0   0

scan!

Dendrogram of similar interfaces ?

matrix format

  
  KTWCFT----KG--------KGTAYCNG--RT----------------------------------------   L                         +5t7x_B    
                                                                                      +----------------1 
  KAWGFTRTNTKGFT------KTTGYCNG--RT----------------------------------------   L   +----2                +1b3t_A    
                                                                                 !    ! 
  --------------TAFCSG--------------LATGSG--VGFA------------RAECACKCSCTAKC   L --3    +-----------------5tkz_B    
                                                                                 ! 
  ----------------------------VC--RC------RC----PANAFAKCKCDC--------------   L   +----------------------3vke_A

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updated Fri Sep 13 20:27:51 2024