5v0q_A : 3D-footprint complex

structure name	ORIGINAL ENGINEERED VARIANT OF I-ONUI MEGANUCLEASE TARGETING THE HIV INTEGRASE GENE; HARBORS 49 POINT MUTATIONS RELATIVE TO WILD-TYPE I- ONUI (I-ONUI_E-VHIVINT_V1)
reference	Lambert et al. 'Protein 30 503 2017
source	SYNTHETIC CONSTRUCT
experiment	X-ray (resolution=2.40, R-factor=0.190)
structural superfamily	Homing endonucleases;
sequence family	LAGLIDADG endonuclease;
reference complex	5t8d_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 5v0q_A interface=18,22,24,26,32,34,36,38,58,60,62,66,68,70,170,174,176,180,185,187,189,191,193,215,217,219,222,224,226,230, resinpwiltgfadaegSfglYiYnRnryttRlRfTiTlhnkdksileniqstwkvgIiTnNgdnAvSlHvsrfedlkviidhfekyplitqklgdyklfkqafsvmenkehlkengikelvrikakmnwgltdelkkafpgnisrerplinknipnfkwlagftsgegHfgvElIknsRnsrvHvRlRfEiAqhvrdknlmnslitylgcgyiYeQnYseRsWlRfsvSkfsdindkiipvfqentligvkledfedwckvaklieekkhltesgldeikkiklnmnkgr
interface signature	SYYRRRTTITNASHHEIRHRREAYQYRWRS

Estimated binding specificities ?

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# IC=20.947 IC/col=1.047 n_of_columns=20

specificity:

A |  66  14   0   0   0   0   0  96   2   0  58  24   0  13   0   0   9   0   0  96
C |  11  11   0   0   0   0   0   0   2   0  11  24   0   5  96   0   0  96  96   0
G |   8   5   0  96   0  96  96   0   2  96  13  24   0  14   0   0  87   0   0   0
T |  11  66  96   0  96   0   0   0  90   0  14  24  96  64   0  96   0   0   0   0

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updated Fri Jan 9 04:32:28 2026