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structure nameCRYSTAL STRUCTURE OF HUMAN DUX4 HOMEODOMAINS BOUND TO DNA
(Double homeobox protein 4)
referenceGan et al. 'Biochem. 505 1161 2018
sourceHomo sapiens
experimentX-ray (resolution=2.30, R-factor=0.213)
structural superfamilyHomeodomain-like;
sequence familyHomeobox domain;
multimeric complexes5z2t_CD 6dfy_CD
reference complex6a8r_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRRIQNRSRRIQNR

Estimated binding specificities ?

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# IC=11.075 IC/col=0.923 n_of_columns=12 specificity:   
A |   0   0  96   6  24  66  12  90   0   0  96   6
C |   0   0   0  12  24  12  12   0   0   0   0   6
G |   0  96   0   6  24   6  60   6   0   0   0  78
T |  96   0   0  72  24  12  12   0  96  96   0   6
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updated Fri Jan 9 05:14:15 2026