6a8r_A : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF DUX4 HD2 DOMAIN ASSOCIATED WITH ERG DNA BINDING SITE (Double homeobox protein 4)
reference	Zhang et al. Leukemia 33 550 2019
source	Homo sapiens
experiment	X-ray (resolution=1.60, R-factor=0.201)
structural superfamily	Homeodomain-like;
sequence family	Homeobox domain;
multimeric complexes	5z2t_CD 6dfy_CD
redundant complexes	5z2t_C 5z6z_A 5zfw_A 5zfy_A 5zfz_A 6dfy_C 6e8c_A 6u81_A 6u82_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 6a8r_A interface=1,4,46,49,50,53,54, RrkRtavtgsqtalllrafekdrfpgiaareelaretglpesriqIwfQNrrARhpgq
interface signature	RRIQNAR

Estimated binding specificities ?

readout + contact

# IC=3.517 IC/col=0.879 n_of_columns=4

specificity:

A |  48   1   1  78
C |   9   0  95   1
G |  29   0   0  12
T |  10  95   0   5

scan!

Dendrogram of similar interfaces ?

matrix format

  
  RA--IAQTNA----   L                         +-5ego_B    
                       +---------------------1 
  RT--NT--NAIARG   L   !                     +-1b72_B    
                     --3 
  RT--VTQTNA--RG   L   !                   +---8ejp_B    
                       +-------------------2 
  --RTNT--NAIARG   L                       +---4cyc_B

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updated Sat Jan 10 09:43:55 2026