6a8r_A : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF DUX4 HD2 DOMAIN ASSOCIATED WITH ERG DNA BINDING SITE (Double homeobox protein 4)
reference	Zhang et al. Leukemia 33 550 2019
source	Homo sapiens
experiment	X-ray (resolution=1.60, R-factor=0.201)
structural superfamily	Homeodomain-like;
sequence family	Homeobox domain;
multimeric complexes	5z2t_CD 6dfy_CD
redundant complexes	5z2t_C 6dfy_C
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 6a8r_A interface=1,4,46,49,50,53,54, RrkRtavtgsqtalllrafekdrfpgiaareelaretglpesriqIwfQNrrARhpgq
interface signature	RRIQNAR

Estimated binding specificities ?

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# IC=3.649 IC/col=0.912 n_of_columns=4

specificity:

A |   4   0  96   8
C |  13   0   0  32
G |   1  96   0   9
T |  78   0   0  47

scan!

Dendrogram of similar interfaces ?

matrix format

  
  RT--------ITQCNAMC   L     +-----------------------------2r5y_A    
                           +-2 
  ----------VA--NAQA   L   ! !                           +-1o4x_A    
                         --3 +---------------------------1 
  ----------VTCCNAQA   L   !                             +-8g87_X    
                           ! 
  --DTRTRGTTKT------   L   +-----------------------------2o8k_A

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updated Sun Aug 3 10:54:33 2025