interface graph thumbnail
legend  pdf

structure nameCRYSTAL STRUCTURE OF DUX4 HD2 DOMAIN ASSOCIATED WITH ERG DNA BINDING SITE
(Double homeobox protein 4)
referenceZhang et al. Leukemia 33 550 2019
sourceHomo sapiens
experimentX-ray (resolution=1.60, R-factor=0.201)
structural superfamilyHomeodomain-like;
sequence familyHomeobox domain;
multimeric complexes5z2t_CD 6dfy_CD
redundant complexes5z2t_C 6dfy_C
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRRIQNAR

Estimated binding specificities ?

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# IC=3.565 IC/col=0.891 n_of_columns=4 specificity:   
A |  47   1   0  79
C |   9   0  95   1
G |  31   0   0  13
T |   9  95   1   3
scan!

Dendrogram of similar interfaces ?

matrix format
  
  RT--------ITQCNAMC   L     +-----------------------------2r5y_A    
                           +-2 
  ----------VA--NAQA   L   ! !                           +-1o4x_A    
                         --3 +---------------------------1 
  ----------VTCCNAQA   L   !                             +-8g87_X    
                           ! 
  --DTRTRGTTKT------   L   +-----------------------------2o8k_A    
                         

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updated Fri Sep 13 21:17:26 2024