interface graph thumbnail
legend  pdf

structure nameCRYSTAL STRUCTURE OF HUMAN TOPOISOMERASE II BETA IN COMPLEX WITH DNA: A NEW QUATERNARY CONFORMATION SHOWING OPENING OF THE PROTEIN-LINKED DNA-GATE
(DNA topoisomerase 2-beta)
referenceChen et al. 'Nat 9 3085 2018
sourceHomo sapiens
experimentX-ray (resolution=2.75, R-factor=0.224)
structural superfamilyType II DNA topoisomerase;
sequence familyDNA gyrase/topoisomerase IV, subunit A;
redundant complexes5zqf_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureKAIA

Estimated binding specificities ?

contactlogo
# IC=3.101 IC/col=0.620 n_of_columns=5 specificity:   
A |   0   0  24  16  13
C |  96   0  24  13  54
G |   0  96  24  54  16
T |   0   0  24  13  13
scan!

Dendrogram of similar interfaces ?

matrix format
  
  RAKG----------QAAG------IGAG----------------   L                            +------5zen_A    
                                                                          +---2 
  --KA------------SA--RG--IG------------------                            !   +------2xcr_U    
                                                         +----------------4 
  ----RC----------ST------IA------------------           !                !        +-3ksb_B    
                                                       +-6                +--------1 
  ------------------------------------LAECDAKG         ! !                         +-6n1p_A    
                                                       ! ! 
  ------QA--------------NG--------------------       +-7 +---------------------------7k63_U    
                                                     ! ! 
  ----------RC----------SG--------------------       ! !        +-------------------7cow_T    
                                                     ! +--------5 
  --------RC----------------------------------     --8          !          +--------6l9z_S    
                                                     !          +----------3 
  ----------DTRGRCTTKT------------------------   L   !                     +--------2o9l_A    
                                                     ! 
  ----------------------------NCATSTRA--------       +-----------------------------1a02_J    
                                                   

home
updated Fri Sep 13 21:11:17 2024