interface graph thumbnail
legend  pdf

structure nameCRYSTAL STRUCTURE OF HUMAN TOPOISOMERASE II BETA IN COMPLEX WITH 5- IODOURIDINE-CONTAINING-DNA IN SPACE GROUP P3221
(DNA topoisomerase 2-beta)
referenceChen et al. 'Nat 9 3085 2018
sourceHomo sapiens
experimentX-ray (resolution=3.87, R-factor=0.207)
structural superfamilyType II DNA topoisomerase;
sequence familyDNA gyrase/topoisomerase IV, subunit A;
reference complex5zen_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRKAIA

Estimated binding specificities ?

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# IC=3.142 IC/col=0.628 n_of_columns=5 specificity:   
A |   0   0  24  13  13
C |  96   0  24  13  57
G |   0  96  24  54  13
T |   0   0  24  16  13
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updated Sat Aug 2 10:14:48 2025