interface graph thumbnail
legend  pdf

structure nameCRYSTAL STRUCTURE OF HUMAN TOPOISOMERASE II BETA IN COMPLEX WITH 5- IODOURIDINE-CONTAINING-DNA IN SPACE GROUP P3221
(DNA topoisomerase 2-beta)
referenceChen et al. 'Nat 9 3085 2018
sourceHomo sapiens
experimentX-ray (resolution=3.87, R-factor=0.207)
structural superfamilyType II DNA topoisomerase;
sequence familyDNA gyrase/topoisomerase IV, subunit A;
reference complex5zen_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureKAIA

Estimated binding specificities ?

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# IC=2.755 IC/col=0.689 n_of_columns=4 specificity:   
A |  11   9   0  19
C |  67  76   0  11
G |   9  11  96  57
T |   9   0   0   9
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updated Thu Sep 12 22:39:17 2024