interface graph thumbnail
legend  pdf

structure nameCRYSTAL STRUCTURE OF HUMAN TOPOISOMERASE II BETA IN COMPLEX WITH 5- IODOURIDINE-CONTAINING-DNA IN SPACE GROUP P3221
(DNA topoisomerase 2-beta)
referenceChen et al. 'Nat 9 3085 2018
sourceHomo sapiens
experimentX-ray (resolution=3.87, R-factor=0.207)
structural superfamilyType II DNA topoisomerase;
sequence familyDNA gyrase/topoisomerase IV, subunit A;
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureKAIA

Estimated binding specificities ?

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# IC=3.125 IC/col=0.781 n_of_columns=4 specificity:   
A |   9   0   0  19
C |  76  86   0  28
G |   9   0  96  40
T |   2  10   0   9
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updated Tue Dec 17 03:13:48 2024