interface graph thumbnail
legend  pdf

structure nameCRYSTAL STRUCTURE OF HUMAN TOPOISOMERASE II BETA IN COMPLEX WITH 5- IODOURIDINE-CONTAINING-DNA IN SPACE GROUP P3221
(DNA topoisomerase 2-beta)
referenceChen et al. 'Nat 9 3085 2018
sourceHomo sapiens
experimentX-ray (resolution=3.87, R-factor=0.207)
structural superfamilyType II DNA topoisomerase;
sequence familyDNA gyrase/topoisomerase IV, subunit A;
multimeric complexes4g0u_AB 4g0v_AB 4g0w_AB
reference complex3qx3_B
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRKAIA

Estimated binding specificities ?

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# IC=2.849 IC/col=0.712 n_of_columns=4 specificity:   
A |   8   8   0  24
C |  72  80   0  16
G |   8   8  96  48
T |   8   0   0   8
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updated Mon Dec 18 14:18:48 2023