6c31_EFGH : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF TETR FAMILY PROTEIN RV0078 IN COMPLEX WITH DNA
reference	Hsu et al. MBio 9 ? 2018
source	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) / Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) / Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) / Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) / Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) / Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) / Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) / Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
experiment	X-ray (resolution=3.00, R-factor=?)
structural superfamily	Homeodomain-like;Tetracyclin repressor-like, C-terminal domain;
reference complex	6c31_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 6c31_E interface=3,33,42,43,47,48, rtQeersaatrealitgarklwglrgyaevgtPeiateagvTRgamYHqfadkaalfrdvvevveqdvmarmatlvaasgaatpadairaavdawlevsgdpevrqlilldapvvlgwagfrdvaqryslgmteqliteairagqlarqpvrplaqvligaldeaamfiataddpkrarretrqvlrrlidgmln > 6c31_F interface=3,42,43,47,48, rtQeersaatrealitgarklwglrgyaevgtpeiateagvTRgamYHqfadkaalfrdvvevveqdvmarmatlvaasgaatpadairaavdawlevsgdpevrqlilldapvvlgwagfrdvaqryslgmteqliteairagqlarqpvrplaqvligaldeaamfiataddpkrarretrqvlrrlidgmln > 6c31_G interface=43,47, rtqeersaatrealitgarklwglrgyaevgtpeiateagvtRgamYhqfadkaalfrdvvevveqdvmarmatlvaasgaatpadairaavdawlevsgdpevrqlilldapvvlgwagfrdvaqryslgmteqliteairagqlarqpvrplaqvligaldeaamfiataddpkrarretrqvlrrlidgmln > 6c31_H interface=32,42,46,47, tqeersaatrealitgarklwglrgyaevgtPeiateagvtRgamYHqfadkaalfrdvvevveqdvmarmatlvaasgaatpadairaavdawlevsgdpevrqlilldapvvlgwagfrdvaqryslgmteqliteairagqlarqpvrplaqvligaldeaamfiataddpkrarretrqvlrrlidgmln
interface signature	QPTRYH/QTRYH/RY/PRYH

Estimated binding specificities ?

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# IC=11.666 IC/col=0.686 n_of_columns=17

specificity:

A |  90  24  24  24  13   0  96  24  90   0  23   0  24  24   4   0   6
C |   4  48  24  24  21  96   0  24   1  96   1   0  24  24   1   0   1
G |   1   9  24  24  42   0   0  24   4   0   0  96  24  24  82  96   1
T |   1  15  24  24  20   0   0  24   1   0  72   0  24  24   9   0  88

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updated Thu Jun 25 12:38:11 2026