6f40_ABEOPUVW : 3D-footprint complex

structure name	RNA POLYMERASE III OPEN COMPLEX
reference	Vorlaender et al. Nature 553 295 2018
experiment	X-ray (resolution=3.70, R-factor=?)
structural superfamily	TATA-box binding protein-like;"Winged helix" DNA-binding domain;NTF2-like;Homeodomain-like;Cyclin-like;Zinc beta-ribbon;
reference complex	5oqj_O 6cnb_O 6cnb_P 6eu0_V 6eu0_Z
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 6f40_A interface=1321, kevvvsetpkrikglefsalsaadivaqsevevstrdlfdlekdrapkangaldpkmgvsssslecatchgnlaschghfghlklalpvfhigyfkatiqilqgickncsaillsetdkrqflhelrrpgvdnlrrmgilkkildqckkqrrclhcgalngvvkkaaalkiihdtfrwvgkksapekdiwvgewkevlahnpeleryvkrcmddlnplktlnlfkqiksadcellgidatvpsgrpetyiwrylpappvcirpsvmmqdspasneddltvklteivwtsslikagldkgisinnmmehwdylqltvamyinsdsvnpkpirgfcqrlkgkqgrfrgnlsgkrvdfsgrtvispdpnlsidevavpdrvakvltypekvtrynrhklqelivngpnvhpganyllkrnedarrnlrygdrmklaknlqigdvverhledgdvvlfnrqpslhrlsilshyakirpwrtfrlnecvctpynadfdgdemnlhvpqteearaeainlmgvknnlltpksgepiiaatqdfitgsylishkdsfydratltqllsmmsdgiehfdipppaimkpyylwtgkqvfsllikpnhnspvvinldaknkvfvppkskslpnemsqndgfviirgsqilsgvmdksvlgdgkkhsvfytilrdygpqeaanamnrmaklcarflgnrgfsigindvtpaddlkqkkeelveiayhkcdelitlfnkgeletqpgcneeqtleakiggllskvreevgdvcineldnwnaplimatcgskgstlnvsqmvavvgqqiisgnrvpdgfqdrslphfpknsktpqskgfvrnsffsglsppeflfhaisgreglvdtavktaetgymsrrlmksledlscqydntvrtsangivqftyggdgldplemegnaqpvnfnrswdhaynitfnnqdkgllpyaimetaneilgpleerlvrydnsgclvkredlnkaeyvdqydaerdfyhslreyingkatalanlrksrgmlglleppakelqgidpdetvpdnvktsvsqlyriseksvrkfleialfkyrkarlepgtaigaigaqsigepmnvtlgvprikeiinaskvistpiinavlvndnderaarvvkgrvektllsdvafyvqdvykdnlsfiqvridlgtidklqleltiediavaitrasklkiqasdvniigkdriainvfpendvfyrmqqlrralpdvvvkglpdisravinirddgkrellvegyglrdvmctdgvigsrtttnhvlevfsvlgieaarysiireinytmsnhgmsvdprhiqllgdvmtykgevlgitRfglskmrdsvlqlasfekttdhlfdaafymkkdavegvseciilgqtmsigtgsfkvvkgtnisekdlvpkrclfes > 6f40_B interface=446,447, deintaqdkwhllpaflkvkglvkqhldsfnyfvdtdlkkiikanqlilsdvdpefylkyvdirvgkksssstkdyltpphecrlrdmtysapiyvdieytrgrniimhkdveigrmpimlrsnkcilydadeskmaklnecpldpggyfivngtekvilvqeqlsknriiveadekkgivqasvtsstherksktyvitkngkiylkhnsiaeeipiaivlkacgilsdleimqlvcgndssyqdifavnleesskldiytqqqaleyigakvktmrrqkltilqegieaiattviahltvealdfrekalyiammtrrvvmamynpkmiddrdyvgnkrlelagqlisllfedlfkkfnndfklsidkvlkkpnrameydallsinvhsnnitsglnraistgnwslkrfkmeragvthvlsrlsyisalgmmtrissqfeksRKvsgpralqpsqfgmlctadtpegeacglvknlalmthittddeeepikklcyvlgveditlidsaslhlnygvylngtligsirfptkfvtqfrhlrrtgkvsefisiysnshqmavhiatdggricrpliivsdgqsrvkdihlrklldgeldfddflklglveyldvneendsyialyekdivpsmthleiepftilgavaglipyphhnqsprntyqcamgkqaigaiaynqfkridtllylmtypqqpmvktktielidydklpagqnatvavmsysgydiedalvlnkssidrgfgrcetrrktttvlkryanhtqdiiggmrvdengdpiwqhqslgpdglgevgmkvqsgqiyinksvptnsadapnpnnvnvqtqyreapviyrgpepshidqvmmsvsdndqalikvllrqnrrpelgdkfssrhgqkgvcgiivkqedmpfndqgivpdiimnphgfpsrmtvgkmielisgkagvlngtleygtcfggskledmskilvdqgfnysgkdmlysgitgeclqayiffgpiyyqklkhmvldkmharargpravltrqptegrsrdgglrlgemerdcviaygasqlllerlmissdafevdvcdkcglmgysgwcttcksaeniikmtipyaakllfqellsmniaprlrledifqq > 6f40_E interface= dqenernisrlwrafrtvkemvkdrgyfitqeevelpledfkakycdsmgrpqrkmmsfqanpteesiskfpdmgslwvefcdepsvgvktmktfvihiqeknfqtgifvyqnnitpsamklvpsippatietfneaalvvnithhelvpkhirlssdekrellkryrlkesqlpriqradpvalylglkrgevvkiirksetsgryasyricm > 6f40_O interface= sleqrtlnpdlflykelvkahlgeraasvigmlvalgrlsvrelvekidgmdvdsvkttlvsltqlrcvkylqetaisgkkttyyyyneegihillysgliideiitqmrvndeeehkqlvaeivqnvislgsltvedylssvtsdsmkytisslfvqlcemgyliqisklhytpiedlwqflyekhykniprnsplsdlkkrsqakmnaktdfakiinkpnelsqiltvdpktslrivkptvsltinldrfmkgrrskqlinlaktrvgsvtaqvykialrlteqkspkirdpltqtgllqdleeaksfqdeaelveektpgltfnaidlarhlpsaslinshlkilassnfpflnetkpgvyyvpysklmpvlkssvyeyviastlgpsamrlsrcirdnklvsekiinstalmkekdirstlaslirynsveiqevprtadrSAsravflfrckethsynfmrqnlewnmanllfkkeklkqenstllkkanrddllpselnqlkmvnerelnvfarlsrllslwevfqma > 6f40_P interface= lsdnaktlhsqmmskgigalftqqelqkqmgigsltdlmsivqelldknliklvkqndelkfqgvleseaqkkatmsaeealvysyieasgregiwsktikartnlhqhvvlkclkslesqryvksvksvkfptrkiymlyslqpsveldiefinslltivwrfisentqeilefitaaqvanveltpsnirslcevlvyddklekvthdcyrvtlesilqmifnyfkmfpaskhdkevvyfdewt > 6f40_U interface=9,11,39,54,56,64,99,101,130,131,145,147,153,155, sgivptlqNiVatvtlgcrldlktvalharnaeynpkrFaavimrirepkttaLiFasgkmvvTgakseddsklasrkyariiqkigfaakftdfkiqNiVgscdvkfpirleglafshgtfssyepelFPgliyrmvkpkivlLiFvsgkiVlTgakqreeiyqafeaiypvlsefrkm > 6f40_V interface=42,85,220, pvcknchgteferdlsnanndlvckacgvvsednpivseleSreatlnnarrklravsyalhipeyitdaafqwyklalannfvQgrrsqnviasclyvacrkekthhmlidfssrlqvsvysigatflkmvkklhitelpladpslfiqhfaekldladkkikvvkdavklaqrmskdwmfegrrpagiagacillacrmnnlrrthteivavshvaeEtlqqrlnefkntkaaklsvqkfrendvedgearppsfvknrkkecprnlhllpttdtylskvsddpdnledvddeelnahllneeasklkeriwiglnadflleqeskrlkqeadia > 6f40_W interface=94,97, ckpnfpigqisenfekskmakkaklekrrhlrelrmrarqtaiqlklnpdgtmaideetmvvdrhknasieneykekvdenpfanlynygsygRgsYtdpwtveemikfykalsmwgtdfnlisqlypyrsrkqvkakfvneekkrpilielalrsklppnfdeycceikknigtvadfneklielqnehkhhmkeieeakntakeedqtaqrlndan
interface signature	R/RK//SA//NVFLFTNVFPLFVT/SQE/RY

Estimated binding specificities ?

contact

# IC=12.020 IC/col=0.462 n_of_columns=26

specificity:

A |  81   0  24  24  24  24  24  24  24  24  24  24  24  24   3  96  24   0   0  60   0  93  18   3  24   3
C |   3  96  24  24  24  24  24  24  24  24  24  24  24  24   3   0  24   0   0   9   0   0  15   3  24   0
G |   6   0  24  24  24  24  24  24  24  24  24  24  24  24   3   0  24   0   0  15   0   0  51   6  24  90
T |   6   0  24  24  24  24  24  24  24  24  24  24  24  24  87   0  24  96  96  12  96   3  12  84  24   3

scan!

home
updated Thu Jun 25 14:30:50 2026