6f40_ABEOPUVW : 3D-footprint complex

structure name	RNA POLYMERASE III OPEN COMPLEX
reference	Vorlaender et al. Nature 553 295 2018
experiment	X-ray (resolution=3.70, R-factor=?)
structural superfamily	TATA-box binding protein-like;"Winged helix" DNA-binding domain;NTF2-like;Homeodomain-like;Cyclin-like;Zinc beta-ribbon;
reference complex	5oqj_O 6cnb_O 6cnb_P 6eu0_V 6eu0_Z
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 6f40_A interface=1321, kevvvsetpkrikglefsalsaadivaqsevevstrdlfdlekdrapkangaldpkmgvsssslecatchgnlaschghfghlklalpvfhigyfkatiqilqgickncsaillsetdkrqflhelrrpgvdnlrrmgilkkildqckkqrrclhcgalngvvkkaaalkiihdtfrwvgkksapekdiwvgewkevlahnpeleryvkrcmddlnplktlnlfkqiksadcellgidatvpsgrpetyiwrylpappvcirpsvmmqdspasneddltvklteivwtsslikagldkgisinnmmehwdylqltvamyinsdsvnpkpirgfcqrlkgkqgrfrgnlsgkrvdfsgrtvispdpnlsidevavpdrvakvltypekvtrynrhklqelivngpnvhpganyllkrnedarrnlrygdrmklaknlqigdvverhledgdvvlfnrqpslhrlsilshyakirpwrtfrlnecvctpynadfdgdemnlhvpqteearaeainlmgvknnlltpksgepiiaatqdfitgsylishkdsfydratltqllsmmsdgiehfdipppaimkpyylwtgkqvfsllikpnhnspvvinldaknkvfvppkskslpnemsqndgfviirgsqilsgvmdksvlgdgkkhsvfytilrdygpqeaanamnrmaklcarflgnrgfsigindvtpaddlkqkkeelveiayhkcdelitlfnkgeletqpgcneeqtleakiggllskvreevgdvcineldnwnaplimatcgskgstlnvsqmvavvgqqiisgnrvpdgfqdrslphfpknsktpqskgfvrnsffsglsppeflfhaisgreglvdtavktaetgymsrrlmksledlscqydntvrtsangivqftyggdgldplemegnaqpvnfnrswdhaynitfnnqdkgllpyaimetaneilgpleerlvrydnsgclvkredlnkaeyvdqydaerdfyhslreyingkatalanlrksrgmlglleppakelqgidpdetvpdnvktsvsqlyriseksvrkfleialfkyrkarlepgtaigaigaqsigepmnvtlgvprikeiinaskvistpiinavlvndnderaarvvkgrvektllsdvafyvqdvykdnlsfiqvridlgtidklqleltiediavaitrasklkiqasdvniigkdriainvfpendvfyrmqqlrralpdvvvkglpdisravinirddgkrellvegyglrdvmctdgvigsrtttnhvlevfsvlgieaarysiireinytmsnhgmsvdprhiqllgdvmtykgevlgitRfglskmrdsvlqlasfekttdhlfdaafymkkdavegvseciilgqtmsigtgsfkvvkgtnisekdlvpkrclfes > 6f40_B interface=446,447, deintaqdkwhllpaflkvkglvkqhldsfnyfvdtdlkkiikanqlilsdvdpefylkyvdirvgkksssstkdyltpphecrlrdmtysapiyvdieytrgrniimhkdveigrmpimlrsnkcilydadeskmaklnecpldpggyfivngtekvilvqeqlsknriiveadekkgivqasvtsstherksktyvitkngkiylkhnsiaeeipiaivlkacgilsdleimqlvcgndssyqdifavnleesskldiytqqqaleyigakvktmrrqkltilqegieaiattviahltvealdfrekalyiammtrrvvmamynpkmiddrdyvgnkrlelagqlisllfedlfkkfnndfklsidkvlkkpnrameydallsinvhsnnitsglnraistgnwslkrfkmeragvthvlsrlsyisalgmmtrissqfeksRKvsgpralqpsqfgmlctadtpegeacglvknlalmthittddeeepikklcyvlgveditlidsaslhlnygvylngtligsirfptkfvtqfrhlrrtgkvsefisiysnshqmavhiatdggricrpliivsdgqsrvkdihlrklldgeldfddflklglveyldvneendsyialyekdivpsmthleiepftilgavaglipyphhnqsprntyqcamgkqaigaiaynqfkridtllylmtypqqpmvktktielidydklpagqnatvavmsysgydiedalvlnkssidrgfgrcetrrktttvlkryanhtqdiiggmrvdengdpiwqhqslgpdglgevgmkvqsgqiyinksvptnsadapnpnnvnvqtqyreapviyrgpepshidqvmmsvsdndqalikvllrqnrrpelgdkfssrhgqkgvcgiivkqedmpfndqgivpdiimnphgfpsrmtvgkmielisgkagvlngtleygtcfggskledmskilvdqgfnysgkdmlysgitgeclqayiffgpiyyqklkhmvldkmharargpravltrqptegrsrdgglrlgemerdcviaygasqlllerlmissdafevdvcdkcglmgysgwcttcksaeniikmtipyaakllfqellsmniaprlrledifqq > 6f40_E interface= dqenernisrlwrafrtvkemvkdrgyfitqeevelpledfkakycdsmgrpqrkmmsfqanpteesiskfpdmgslwvefcdepsvgvktmktfvihiqeknfqtgifvyqnnitpsamklvpsippatietfneaalvvnithhelvpkhirlssdekrellkryrlkesqlpriqradpvalylglkrgevvkiirksetsgryasyricm > 6f40_O interface= sleqrtlnpdlflykelvkahlgeraasvigmlvalgrlsvrelvekidgmdvdsvkttlvsltqlrcvkylqetaisgkkttyyyyneegihillysgliideiitqmrvndeeehkqlvaeivqnvislgsltvedylssvtsdsmkytisslfvqlcemgyliqisklhytpiedlwqflyekhykniprnsplsdlkkrsqakmnaktdfakiinkpnelsqiltvdpktslrivkptvsltinldrfmkgrrskqlinlaktrvgsvtaqvykialrlteqkspkirdpltqtgllqdleeaksfqdeaelveektpgltfnaidlarhlpsaslinshlkilassnfpflnetkpgvyyvpysklmpvlkssvyeyviastlgpsamrlsrcirdnklvsekiinstalmkekdirstlaslirynsveiqevprtadrSAsravflfrckethsynfmrqnlewnmanllfkkeklkqenstllkkanrddllpselnqlkmvnerelnvfarlsrllslwevfqma > 6f40_P interface= lsdnaktlhsqmmskgigalftqqelqkqmgigsltdlmsivqelldknliklvkqndelkfqgvleseaqkkatmsaeealvysyieasgregiwsktikartnlhqhvvlkclkslesqryvksvksvkfptrkiymlyslqpsveldiefinslltivwrfisentqeilefitaaqvanveltpsnirslcevlvyddklekvthdcyrvtlesilqmifnyfkmfpaskhdkevvyfdewt > 6f40_U interface=9,11,39,54,56,64,99,101,130,131,145,147,153,155, sgivptlqNiVatvtlgcrldlktvalharnaeynpkrFaavimrirepkttaLiFasgkmvvTgakseddsklasrkyariiqkigfaakftdfkiqNiVgscdvkfpirleglafshgtfssyepelFPgliyrmvkpkivlLiFvsgkiVlTgakqreeiyqafeaiypvlsefrkm > 6f40_V interface=42,85,220, pvcknchgteferdlsnanndlvckacgvvsednpivseleSreatlnnarrklravsyalhipeyitdaafqwyklalannfvQgrrsqnviasclyvacrkekthhmlidfssrlqvsvysigatflkmvkklhitelpladpslfiqhfaekldladkkikvvkdavklaqrmskdwmfegrrpagiagacillacrmnnlrrthteivavshvaeEtlqqrlnefkntkaaklsvqkfrendvedgearppsfvknrkkecprnlhllpttdtylskvsddpdnledvddeelnahllneeasklkeriwiglnadflleqeskrlkqeadia > 6f40_W interface=94,97, ckpnfpigqisenfekskmakkaklekrrhlrelrmrarqtaiqlklnpdgtmaideetmvvdrhknasieneykekvdenpfanlynygsygRgsYtdpwtveemikfykalsmwgtdfnlisqlypyrsrkqvkakfvneekkrpilielalrsklppnfdeycceikknigtvadfneklielqnehkhhmkeieeakntakeedqtaqrlndan
interface signature	R/RK//SA//NVFLFTNVFPLFVT/SQE/RY

Estimated binding specificities ?

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# IC=11.905 IC/col=0.458 n_of_columns=26

specificity:

A |  70   0  24  24  24  24  24  24  24  24  24  24  24  24   0  96  24   0   0  57   0  92  17  14  24   3
C |  11  96  24  24  24  24  24  24  24  24  24  24  24  24   0   0  24   0   0   6   0   0   3   9  24   0
G |   3   0  24  24  24  24  24  24  24  24  24  24  24  24   0   0  24   0   0  25   0   3  54   9  24  93
T |  12   0  24  24  24  24  24  24  24  24  24  24  24  24  96   0  24  96  96   8  96   1  22  64  24   0

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updated Tue Sep 10 12:55:28 2024