6uvw_D : 3D-footprint complex

structure name	ENGINEERED VARIANT OF I-ONUI MEGANUCLEASE WITH IMPROVED THERMOSTABILITY (I-ONUI-E-THERM)
reference	Stoddard et al. Structure 28 760 2020
source	SYNTHETIC CONSTRUCT
experiment	X-ray (resolution=2.55, R-factor=0.225)
structural superfamily	Homing endonucleases;
sequence family	LAGLIDADG endonuclease;
reference complex	6uwj_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 6uvw_D interface=18,22,24,26,28,34,36,40,42,66,70,74,173,175,177,179,188,190,196,216,218,220,222,225,227,233, resinpwiltgfadaegSfllRiRkNnKssvgyStElgfQiTlhnkdksileniqstwgvgvianSgdnAvslKvtrfedlkviidhfekyplitqkyadymlfkqafnvmenkehltiegikelvrikaklnwgltdelkkafpeiskerslinknipnfkwlagftsgegCfFvNlIksksklgvQvQlvfsiTqhirdknlmnslitylgcgYiKkKnKseFsWldfvvTkfsdirdkiipffqeytligtklkdfedwckvaklieekkhlteegldeikkiklnmnkgrvf
interface signature	SRRNKSEQTSAKCFNIQQTYKKKFWT

Estimated binding specificities ?

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# IC=20.424 IC/col=0.973 n_of_columns=21

specificity:

A |  89  96  96  96  27  10   6   9   0  96  24   0  24  74   0   0   0   0  80  86  87
C |   0   0   0   0   0   0   6   6   0   0  24   0  24   6   3   0   0   0   6   3   3
G |   4   0   0   0  68  86   9   4  96   0  24   0  24  13  92   0  96  96   7   3   3
T |   3   0   0   0   1   0  75  77   0   0  24  96  24   3   1  96   0   0   3   4   3

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updated Sun Jun 28 20:00:55 2026