7n8s_A : 3D-footprint complex

structure name	LINE-1 ENDONUCLEASE DOMAIN COMPLEX WITH DNA (LINE-1 retrotransposable element ORF2 protein)
reference	Korolev et al. 'Nucleic 49 11350 2021
source	Homo sapiens
experiment	X-ray (resolution=2.79, R-factor=0.269)
structural superfamily	DNase I-like;
sequence family	Endonuclease/Exonuclease/phosphatase fa;
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 7n8s_A interface=112,191,192, hitiltlninglnsaikrhrlaswiksqdpsvcciqethltcrdthrlkikgwrkiyqangkqkkagvailvsdktdfkptkikrdkeghyimvkgsiqqeeltilniyapNtgaprfikqvlsdlqrdldshtlimgafntplstldrstrqkvnkdtqelnsalhqadlidiyrtlhpksteytffsaPHhtyskidhivgskallskckrteiitnklsdhsaiklelr
interface signature	NPH

Estimated binding specificities ?

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# IC=2.714 IC/col=0.678 n_of_columns=4

specificity:

A |   9  96  67   9
C |   9   0  11   9
G |   9   0   9  69
T |  69   0   9   9

scan!

Dendrogram of similar interfaces ?

matrix format

  
  --NA----PTHA--   L                    +----7n8s_A    
                            +-----------1 
  YT------------       +----2           +----6fk5_A    
                       !    ! 
  ----NT--------     --3    +----------------4b5f_A    
                       ! 
  ------ICPGAGYC       +---------------------5ht2_B

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updated Sun Aug 3 17:14:02 2025