interface graph thumbnail
legend  pdf

structure nameSPCAS9 BOUND TO AAVS1 OFF-TARGET5 DNA SUBSTRATE
(CRISPR-associated endonuclease Cas9Csn1)
referencePacesa et al. Cell 185 4067 2022
sourceStreptococcus pyogenes
experimentX-ray (resolution=2.75, R-factor=0.191)
multimeric complexes7v59_BE
reference complex6vpc_F
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureKERR

Estimated binding specificities ?

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# IC=2.582 IC/col=0.646 n_of_columns=4 specificity:   
A |  38   2   0  57
C |  20  88  95  15
G |  19   3   0  14
T |  19   3   1  10
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updated Fri Jan 9 17:08:20 2026