7v59_BE : 3D-footprint complex

structure name	CRYO-EM STRUCTURE OF SPYCAS9-SGRNA-DNA DIMER
experiment	NMR
structural superfamily	Cytidine deaminase-like;
reference complex	5y36_A 6vpc_F
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 7v59_B interface=167,448,489,493,767,909,911,912,914,919,959,1105,1238,1329,1331,1333, kkysigldigtnsvgwavitdeykvpskkfkvlgntdrhsikknligallfdsgetaeatrlkrtarrrytrrknricylqeifsnemakvddsffhrleesflveedkkherhpifgnivdevayhekyptiyhlrkklvdstdkadlrliylalahmikfrghfLiegdlnpdnsdvdklfiqlvqtynqlfeenpinasgvdakailsarlsksrrlenliaqlpgekknglfgnlialslgltpnfksnfdlaedaklqlskdtydddldnllaqigdqyadlflaaknlsdaillsdilrvnteitkaplsasmikrydehhqdltllkalvrqqlpekykeiffdqskngyagyidggasqeefykfikpilekmdgteellvklnredllrkqrtfdngsiphqihlgelhailrrqedfypflkdnrekiekiltfripYyvgplargnsrfawmtrkseetitpwnfeevvdkgasaqsFierMtnfdknlpnekvlpkhsllyeyftvyneltkvkyvtegmrkpaflsgeqkkaivdllfktnrkvtvkqlkedyfkkiecfdsveisgvedrfnaslgtyhdllkiikdkdfldneenediledivltltlfedremieerlktyahlfddkvmkqlkrrrytgwgrlsrklingirdkqsgktildflksdgfanrnfmqlihddsltfkediqkaqvsgqgdslhehianlagspaikkgilqtvkvvdelvkvmgrhkpeniviemarenqTtqkgqknsrermkrieegikelgsqilkehpventqlqneklylyylqngrdmyvdqeldinrlsdydvdhivpqsflkddsidnkvltrsdknrgksdnvpseevvkkmknywrqllnaklitqrkfdnltkaergglseLdKAgFikrqLvetrqitkhvaqildsrmntkydendklirevkvitlksKlvsdfrkdfqfykvreinnyhhahdaylnavvgtalikkypklesefvygdykvydvrkmiakseqeigkatakyffysnimnffkteitlangeirkrplietngetgeivwdkgrdfatvrkvlsmpqvnivkktevqtggfsKespkrnsdkliarkkdwdpkkyggfdsptvaysvlvvakvekgkskklksvkellgitimerssfeknpidfleakgykevkkdliiklpkyslfelengrkrmlasagelqkgnelalpskyvnflylashYeklkgspedneqkqlfveqhkhyldeiieqisefskrviladanldkvlsaynkhrdkpireqaeniihlftltnlgapaafkyfdttidRkRyTstkevldatlihqsitglyetridlsq > 7v59_E interface=69,448,489,493,767,892,909,911,912,914,919,959,1034,1105,1106,1215,1238,1329,1331,1333, kkysigldigtnsvgwavitdeykvpskkfkvlgntdrhsikknligallfdsgetaeatrlkrtarrRytrrknricylqeifsnemakvddsffhrleesflveedkkherhpifgnivdevayhekyptiyhlrkklvdstdkadlrliylalahmikfrghfliegdlnpdnsdvdklfiqlvqtynqlfeenpinasgvdakailsarlsksrrlenliaqlpgekknglfgnlialslgltpnfksnfdlaedaklqlskdtydddldnllaqigdqyadlflaaknlsdaillsdilrvnteitkaplsasmikrydehhqdltllkalvrqqlpekykeiffdqskngyagyidggasqeefykfikpilekmdgteellvklnredllrkqrtfdngsiphqihlgelhailrrqedfypflkdnrekiekiltfripYyvgplargnsrfawmtrkseetitpwnfeevvdkgasaqsFierMtnfdknlpnekvlpkhsllyeyftvyneltkvkyvtegmrkpaflsgeqkkaivdllfktnrkvtvkqlkedyfkkiecfdsveisgvedrfnaslgtyhdllkiikdkdfldneenediledivltltlfedremieerlktyahlfddkvmkqlkrrrytgwgrlsrklingirdkqsgktildflksdgfanrnfmqlihddsltfkediqkaqvsgqgdslhehianlagspaikkgilqtvkvvdelvkvmgrhkpeniviemarenqTtqkgqknsrermkrieegikelgsqilkehpventqlqneklylyylqngrdmyvdqeldinrlsdydvdhivpqsflkddsidnkvltrsdknrgksdnvpseevvkkmknywrqllnaklitQrkfdnltkaergglseLdKAgFikrqLvetrqitkhvaqildsrmntkydendklirevkvitlksKlvsdfrkdfqfykvreinnyhhahdaylnavvgtalikkypklesefvygdykvydvrkmiakseqeigkatakYffysnimnffkteitlangeirkrplietngetgeivwdkgrdfatvrkvlsmpqvnivkktevqtggfsKEspkrnsdkliarkkdwdpkkyggfdsptvaysvlvvakvekgkskklksvkellgitimerssfeknpidfleakgykevkkdliiklpkyslfelengrkrmlasagElqkgnelalpskyvnflylashYeklkgspedneqkqlfveqhkhyldeiieqisefskrviladanldkvlsaynkhrdkpireqaeniihlftltnlgapaafkyfdttidRkRyTstkevldatlihqsitglyetridlsq
interface signature	LYFMTLKAFLKKYRRT/RYFMTQLKAFLKYKEEYRRT

Estimated binding specificities ?

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# IC=16.541 IC/col=0.517 n_of_columns=32

specificity:

A |   4  24   9  84   0  24  24   0   0   0   0  24  24  24  24  24  24  24  24  24  24  24  24   4   0   0  96  24  24   0   4   9
C |   4  24   9   4  96  24  24   0   0   0  96  24  24  24  24  24  24  24  24  24  24  24  24   2  96  96   0  24  24   0   4  69
G |  84  24  74   4   0  24  24   0  96  96   0  24  24  24  24  24  24  24  24  24  24  24  24  86   0   0   0  24  24  96   4   9
T |   4  24   4   4   0  24  24  96   0   0   0  24  24  24  24  24  24  24  24  24  24  24  24   4   0   0   0  24  24   0  84   9

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updated Fri Jun 26 21:48:24 2026