interface graph thumbnail
legend  pdf

structure nameSPCAS9 BOUND TO FANCF OFF-TARGET2 DNA SUBSTRATE
(CRISPR-associated endonuclease Cas9Csn1)
referencePacesa et al. Cell 185 4067 2022
sourceStreptococcus pyogenes
experimentX-ray (resolution=2.45, R-factor=0.204)
multimeric complexes7v59_BE
reference complex6vpc_F
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureKSERR

Estimated binding specificities ?

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# IC=2.433 IC/col=0.608 n_of_columns=4 specificity:   
A |  67   0   7  18
C |   9   0   7  18
G |  11  96  74  18
T |   9   0   8  42
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updated Fri Jan 9 17:09:53 2026