7qxa_A : 3D-footprint complex

structure name	CRYO-EM MAP OF HUMAN TELOMERASE-DNA-TPP1 COMPLEX (SHARPENED) (TELOMERASE REVERSE TRANSCRIPTASE)
reference	van Roon et al. Science 375 1173 2022
source	HOMO SAPIENS
experiment	X-ray (resolution=3.20, R-factor=0.325)
structural superfamily	DNA/RNA polymerases;
multimeric complexes	7qxb_AP 7qxs_AP
redundant complexes	7trd 7tre 7trf 7v99 7qxb 7qxs
reference complex	7trf_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 7qxa_A interface=322,324,467,475,574,581,661,781,786,790,794,799,802, aprcravrsllrshyrevlplatfvrrlgpqgwrlvqrgdpaafralvaqclvcvpwdarpppaapsfrqvsclkelvarvlqrlcergaknvlafgfallpeafttsvrsylpntvtdalrgsgawglllrrvgddvlvhllarcalfvlvapscayqvcgpplyqlgppvyaetkhflyssgdkeqlrpsfllsslrpsltgarrlvetiflgsrpwmpgtprrlprlpqrywqmrplflellgnhaqcpygvllkthcplradprrlvqllrqhsspwqvygfvraclrrlvppglwgsrhnerrflrntkkfislgkHaKlslqeltwkmsvrdcawlrrspgvgcvpaaehrlreeilakflhwlmsvyvvellrsffyvtettfqknrlffyrksvwsklqsigirqhlkrvqlrelseaevrqhrearpalltsrlrfipkpdglrpivnmdyvvgartFrrekraeRltsrvkalfsvlnyerarrpgllgasvlglddihrawrtfvlrvraqdpppelyfvkvdvtgaydtipqdrlteviasiikpqntycvrryavvqkaaHghvrkaFkshvstltdlqpymrqfvahlqetsplrdavvieqssslneassglfdvflrfmchhavrirgksyvqcqgipqgsilsTllcslcygdmenklfagirrdglllrlvddfllvtphlthaktflrtlvrgvpeygcvvnlrktvvnfpvedealggtafvqmpahglfpwcgllldtrtlevqsdyssyartsiraslTfnrgFkagRnmrRklfgVlrLkchslfldlqvnslqtvctniykilllqayrfhacvlqlpfhqqvwknptfflrvisdtaslcysilkaknagmslgakgaagplpseavqwlchqafllkltrhrvtyvpllgslrtaqtqlsrklpgttltaleaaanpalpsdfktild
interface signature	HKFRHFTTFRRVL

Estimated binding specificities ?

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# IC=6.645 IC/col=0.554 n_of_columns=12

specificity:

A |   0   9  24  24   0  21   0   0  81  24  24  19
C |   0   9  24  24   0  21   0   0   7  24  24  19
G |   0   9  24  24  96  33   0   0   4  24  24  38
T |  96  69  24  24   0  21  96  96   4  24  24  20

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Dendrogram of similar interfaces ?

matrix format

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updated Fri Sep 13 07:24:51 2024