7qxa_A : 3D-footprint complex

structure name	CRYO-EM MAP OF HUMAN TELOMERASE-DNA-TPP1 COMPLEX (SHARPENED) (TELOMERASE REVERSE TRANSCRIPTASE)
reference	van Roon et al. Science 375 1173 2022
source	HOMO SAPIENS
experiment	X-ray (resolution=3.20, R-factor=0.325)
structural superfamily	DNA/RNA polymerases;
multimeric complexes	7qxb_AP 7qxs_AP
redundant complexes	7trd 7tre 7trf 7v99 7qxb 7qxs
reference complex	7trf_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 7qxa_A interface=322,324,467,475,574,581,661,781,786,790,794,799,802, aprcravrsllrshyrevlplatfvrrlgpqgwrlvqrgdpaafralvaqclvcvpwdarpppaapsfrqvsclkelvarvlqrlcergaknvlafgfallpeafttsvrsylpntvtdalrgsgawglllrrvgddvlvhllarcalfvlvapscayqvcgpplyqlgppvyaetkhflyssgdkeqlrpsfllsslrpsltgarrlvetiflgsrpwmpgtprrlprlpqrywqmrplflellgnhaqcpygvllkthcplradprrlvqllrqhsspwqvygfvraclrrlvppglwgsrhnerrflrntkkfislgkHaKlslqeltwkmsvrdcawlrrspgvgcvpaaehrlreeilakflhwlmsvyvvellrsffyvtettfqknrlffyrksvwsklqsigirqhlkrvqlrelseaevrqhrearpalltsrlrfipkpdglrpivnmdyvvgartFrrekraeRltsrvkalfsvlnyerarrpgllgasvlglddihrawrtfvlrvraqdpppelyfvkvdvtgaydtipqdrlteviasiikpqntycvrryavvqkaaHghvrkaFkshvstltdlqpymrqfvahlqetsplrdavvieqssslneassglfdvflrfmchhavrirgksyvqcqgipqgsilsTllcslcygdmenklfagirrdglllrlvddfllvtphlthaktflrtlvrgvpeygcvvnlrktvvnfpvedealggtafvqmpahglfpwcgllldtrtlevqsdyssyartsiraslTfnrgFkagRnmrRklfgVlrLkchslfldlqvnslqtvctniykilllqayrfhacvlqlpfhqqvwknptfflrvisdtaslcysilkaknagmslgakgaagplpseavqwlchqafllkltrhrvtyvpllgslrtaqtqlsrklpgttltaleaaanpalpsdfktild
interface signature	HKFRHFTTFRRVL

Estimated binding specificities ?

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# IC=8.128 IC/col=0.677 n_of_columns=12

specificity:

A |   0   0  24  24   0  23   0   0  96  24  24  21
C |   0   0  24  24   0  10   0   0   0  24  24  21
G |   0   0  24  24  96  42   0   0   0  24  24  33
T |  96  96  24  24   0  21  96  96   0  24  24  21

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Dendrogram of similar interfaces ?

matrix format

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updated Mon Jun 29 02:40:12 2026