7qxs_AP : 3D-footprint complex

3D-footprint cannot reliably estimate the specificity of 'Nucleic acid-binding proteins', as they bind to single-stranded DNA and thus accumulate more base contacts.

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updated Thu Jul 31 19:49:21 2025

structure name	CRYO-EM STRUCTURE OF HUMAN TELOMERASE-DNA-TPP1-POT1 COMPLEX (WITH POT1 SIDE CHAINS)
reference	van Roon et al. Science 375 1173 2022
source	HOMO SAPIENS
experiment	X-ray (resolution=3.91, R-factor=?)
structural superfamily	Nucleic acid-binding proteins;DNA/RNA polymerases;
reference complex	7qxb_P 7trf_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 7qxs_A interface=57,174,319,321,450,461,462,464,472,474,478,536,571,573,578,658,783,787,791,792,799, cravrsllrshyrevlplatfvrrlgpqgwrlvqrgdpaafralvaqclvcvpwdaRpppaapsfrqvsclkelvarvlqrlcergaknvlafgfallpeafttsvrsylpntvtdalrgsgawglllrrvgddvlvhllarcalfvlvapscayqvcgpplyqlgppvyaetKhflyssgdkeqlrpsfllsslrpsltgarrlvetiflgsrpwmpgtprrlprlpqrywqmrplflellgnhaqcpygvllkthcplradprrlvqllrqhsspwqvygfvraclrrlvppglwgsrhnerrflrntkkfislgkHaKlslqeltwkmsvrdcawlrrspgvgcvpaaehrlreeilakflhwlmsvyvvellrsffyvtettfqknrlffyrksvwsklqsigirqhlkrvqlrelseaevrqhrearpalltsrlrfipkpdglRpivnmdyvvgARtFrrekraeRlTsrvKalfsvlnyerarrpgllgasvlglddihrawrtfvlrvraqdpppelyfvkvdvtgaYdtipqdrlteviasiikpqntycvrryavvqkaaHgHvrkaFkshvstltdlqpymrqfvahlqetsplrdavvieqssslneassglfdvflrfmchhavrirgksyvqcqgipqgsilsTllcslcygdmenklfagirrdglllrlvddfllvtphlthaktflrtlvrgvpeygcvvnlrktvvnfpvedealggtafvqmpahglfpwcgllldtrtlevqsdyssyartsirasltfnrgFkagRnmrRKlfgvlrLkchslfldlqvnslqtvctniykilllqayrfhacvlqlpfhqqvwknptfflrvisdtaslcysilkaknagmslgakgaagplpseavqwlchqafllkltrhrvtyvpllgslrtaqtqlsrklpgttltaleaaanpalpsdfktild > 7qxs_P interface=25,26,33,36,37,43,53,55,57,82,84,89,91,123,185,186,205,207,218,223,225, atnyiytplnqlkggtivnvygvvKFfkppylSkgTDycsvvTivdqtnvklTcLlFsgnyealpiiykngdivrfhrlkiQvYkketQgItssgfasltfiprtsskyfnflklcdvqpmqYfdltcqllgkaevdgasfllkvwdgtrtpfpswrvliqdlvlegdlshihrlqnltidilvYDnhvhvarslkvgsflriySlHtkllslefhlHggtsYgRgirvlpesnsdvdqlkkdlesanlta