7qxb_A : 3D-footprint complex

structure name	CRYO-EM MAP OF HUMAN TELOMERASE-DNA-TPP1-POT1 COMPLEX (SHARPENED MAP) (TELOMERASE REVERSE TRANSCRIPTASE)
reference	van Roon et al. Science 375 1173 2022
source	HOMO SAPIENS
experiment	X-ray (resolution=3.91, R-factor=0.325)
structural superfamily	DNA/RNA polymerases;
multimeric complexes	7qxb_AP 7qxs_AP
reference complex	7trf_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 7qxb_A interface=57,174,319,321,450,461,462,464,472,474,478,536,571,573,578,658,783,787,791,792,799, cravrsllrshyrevlplatfvrrlgpqgwrlvqrgdpaafralvaqclvcvpwdaRpppaapsfrqvsclkelvarvlqrlcergaknvlafgfallpeafttsvrsylpntvtdalrgsgawglllrrvgddvlvhllarcalfvlvapscayqvcgpplyqlgppvyaetKhflyssgdkeqlrpsfllsslrpsltgarrlvetiflgsrpwmpgtprrlprlpqrywqmrplflellgnhaqcpygvllkthcplradprrlvqllrqhsspwqvygfvraclrrlvppglwgsrhnerrflrntkkfislgkHaKlslqeltwkmsvrdcawlrrspgvgcvpaaehrlreeilakflhwlmsvyvvellrsffyvtettfqknrlffyrksvwsklqsigirqhlkrvqlrelseaevrqhrearpalltsrlrfipkpdglRpivnmdyvvgARtFrrekraeRlTsrvKalfsvlnyerarrpgllgasvlglddihrawrtfvlrvraqdpppelyfvkvdvtgaYdtipqdrlteviasiikpqntycvrryavvqkaaHgHvrkaFkshvstltdlqpymrqfvahlqetsplrdavvieqssslneassglfdvflrfmchhavrirgksyvqcqgipqgsilsTllcslcygdmenklfagirrdglllrlvddfllvtphlthaktflrtlvrgvpeygcvvnlrktvvnfpvedealggtafvqmpahglfpwcgllldtrtlevqsdyssyartsirasltfnrgFkagRnmrRKlfgvlrLkchslfldlqvnslqtvctniykilllqayrfhacvlqlpfhqqvwknptfflrvisdtaslcysilkaknagmslgakgaagplpseavqwlchqafllkltrhrvtyvpllgslrtaqtqlsrklpgttltaleaaanpalpsdfktild
interface signature	RKHKRARFRTKYHHFTFRRKL

Estimated binding specificities ?

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# IC=10.669 IC/col=0.533 n_of_columns=20

specificity:

A |  96   0  24  24  24  24  24  24   0  11  24  24   0   0   0   9  96  24  24   9
C |   0   0  24  24  24  24  24  24   0   9  24  24   0   0   0   9   0  24  24   9
G |   0  96  24  24  24  24  24  24   0   9  24  24  96  96   0  11   0  24  24  69
T |   0   0  24  24  24  24  24  24  96  67  24  24   0   0  96  67   0  24  24   9

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updated Fri Jan 9 17:16:31 2026