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structure nameSECOND STAGE REENGINEERED VARIANT OF I-ONUI TARGETING HUMAN PD1 GENE WITH ACTIVITY ENHANCING SUBSTITUTIONS
(I-ONUI_E-HPD1-C)
referenceUbilla-Rodriguez et al. 'To ? ? ?
sourceSYNTHETIC CONSTRUCT
experimentX-ray (resolution=2.45, R-factor=0.240)
structural superfamilyHoming endonucleases;
sequence familyLAGLIDADG endonuclease;
reference complex7rcf_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureSRTMNYRTWSFRRRQESYRWQRE

Estimated binding specificities ?

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# IC=17.149 IC/col=1.009 n_of_columns=17 specificity:   
A |   3   0   0   0   0   0   0   7   0  24  65  10   0  79   7   0  96
C |  81   0  96  96   0   0   0  10   0  24  10   8   3   0   7  96   0
G |   7  96   0   0   0  96   0  76  96  24  14   7   0   0  79   0   0
T |   5   0   0   0  96   0  96   3   0  24   7  71  93  17   3   0   0
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updated Mon Jun 29 02:46:38 2026