interface graph thumbnail
legend  pdf

structure nameTHE CRYSTAL STRUCTURE OF HUMAN FORKHEAD BOX PROTEIN A IN COMPLEX WITH DNA 2
(Hepatocyte nuclear factor 3-alpha)
referenceYoon et al. 'Nucleic 50 8929 2022
sourceHomo sapiens
experimentX-ray (resolution=2.10, R-factor=0.187)
structural superfamily"Winged helix" DNA-binding domain;
sequence familyFork head domain;
multimeric complexes7vox_CH
reference complex8vfz_O
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureNSRHSFK

Estimated binding specificities ?

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# IC=4.007 IC/col=0.668 n_of_columns=6 specificity:   
A |   9  24   9   0   0  67
C |   9  24   9   0   0   9
G |  11  24   9   0   0   9
T |  67  24  69  96  96  11
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updated Fri Jan 9 18:31:35 2026