7z4d_E : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF SPCAS9 BOUND TO A 10 NUCLEOTIDE COMPLEMENTARY DNA SUBSTRATE (CRISPR-associated endonuclease Cas9Csn1)
reference	Pacesa et al. Nature 609 191 2022
source	Streptococcus pyogenes
experiment	X-ray (resolution=3.10, R-factor=0.248)
multimeric complexes	7v59_BE
reference complex	6vpc_F
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 7z4d_E interface=168,449,490,494,648,819,905,906,1017,1130,1131,1133, dkkysiglaigtnsvgwavitdeykvpskkfkvlgntdrhsikknligallfdsgetaeatrlkrtarrrytrrknricylqeifsnemakvddsffhrleesflveedkkherhpifgnivdevayhekyptiyhlrkklvdstdkadlrliylalahmikfrghfLiegdlnpdnsdvdklfiqlvqtynqlfeenpinasgvdakailsarlsksrrlenliaqlpgekknglfgnlialslgltpnfksnfdlaedaklqlskdtydddldnllaqigdqyadlflaaknlsdaillsdilrvnteitkaplsasmikrydehhqdltllkalvrqqlpekykeiffdqskngyagyidggasqeefykfikpilekmdgteellvklnredllrkqrtfdngsiphqihlgelhailrrqedfypflkdnrekiekiltfripYyvgplargnsrfawmtrkseetitpwnfeevvdkgasaqsFierMtnfdknlpnekvlpkhsllyeyftvyneltkqkkaivdllflkedyfkkiecfslgtyhdllkiikdkdfldneenediledivltltlfedremieerlktyahlfddkvmkqlkrrrytgwgrlsrklinirdkqsgktildflksanrnfMqlihdslhehianlagspaikkgilqtvkvvdelvkvmgrhkpeniviemaaivpqsflkddsidnkseldkagfikrqlvetrqitkhvaqildsrmntkydendklirevkvitlksklvsdfrkdfqfykvreinnyhhahdaylnavvgtalikkypklesefvygDykvydmiakseqekyffysnimnffkteitlangeirkrplietngetgeivwdkgrdfatvrkvlsmpqvnivkktevqtggfsKEsilpkrnsdkliarkkdwdpkkyggfdsptvaysvlvvakvekgkskklksvkellgitimerssfeknpidfleakgykevkkdliiklpkyslfelengrkrmlasagElqkgnelalpskyvnflylashyeklkgspedneqkqlfveqhkhyldeiieqisefskrviladanldkvlsaynkhrdkpireqaeniihlftltnlgapaafkyfdttiDRkRytstkevldatlihqsitglyetridlsqlggd
interface signature	LYFMMDKEEDRR

Estimated binding specificities ?

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# IC=6.515 IC/col=0.543 n_of_columns=12

specificity:

A |   0   9  67  24  24  24  24  24   9   0   0   0
C |  96  11   9  24  24  24  24  24   9   0   0   0
G |   0   9   9  24  24  24  24  24  19   0  96  96
T |   0  67  11  24  24  24  24  24  59  96   0   0

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updated Tue Dec 17 15:07:12 2024