interface graph thumbnail
legend  pdf

structure nameCRYSTAL STRUCTURE OF SPCAS9 BOUND TO A 10 NUCLEOTIDE COMPLEMENTARY DNA SUBSTRATE
(CRISPR-associated endonuclease Cas9Csn1)
referencePacesa et al. Nature 609 191 2022
sourceStreptococcus pyogenes
experimentX-ray (resolution=3.10, R-factor=0.248)
multimeric complexes7v59_BE
reference complex6vpc_F
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureLYFMMDKEEDRR

Estimated binding specificities ?

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# IC=6.518 IC/col=0.543 n_of_columns=12 specificity:   
A |   0   8  69  24  24  24  24  24   8   0   0   0
C |  96   8  11  24  24  24  24  24   8   0   0   0
G |   0  19   8  24  24  24  24  24  19   0  96  96
T |   0  61   8  24  24  24  24  24  61  96   0   0
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updated Sat Aug 2 22:27:36 2025