8cxs_AB : 3D-footprint complex

structure name	CAMA ADENINE METHYLTRANSFERASE COMPLEXED TO COGNATE SUBSTRATE DNA AND INHIBITOR MTA
reference	Horton et al. J.Med.Chem. 66 934 2023
source	Clostridioides difficile
experiment	X-ray (resolution=2.49, R-factor=?)
structural superfamily	S-adenosyl-L-methionine-dependent methyltransferases;
reference complex	8cxy_C
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 8cxs_A interface=5,135,138,141,142,162,163,191,223,225,226,228,316,319,349,395,396,401,408,409,411,425,426,442,443,444,446,483,484,487,491, asgiYytpkiivdyivkktlknhdiiknpyprildiscgcgnfllevydilydlfeeniyelkkkydenywtvdnihrhilnyciygadidekaisilkdsltnkkvesdikinlfccdslkkkwrykfdyivgNppYigHKklekkykkfllekysevykDKadlyfcfykkiidilkqggigsvitprYfleslsgkdlreyiksnvnvqeivdflganiFkNIgVssciltfdkkktketyidvfkiknedicinkfetleellksskfehfninqrllsdewilvnkddetfynkiqekckyslediaisfQgiItgcdkafilskddvklnlvddkflkcwikSkninkyivdkseyrliysndidnentnkrildeiiglyktklenrREcksgIrkwyelQWgReklfferkkimypYKsnenrfaidydnnfsSADvYsffikeeyldkfsyeylvgilnssvydkyfkitakkMSknIydyYpnkvmkirifrdnnyeeienlskqiisillnksidkgkveklqikmdnlimdslgi > 8cxs_B interface=404, giyytpkiivdyivkktlknhdiiknpyprildiscgcgnfllevydilydlfeeniyelkkkydenywtvdnihrhilnyciygadidekaisilkdsltnkkvvndldesdikinlfccdslkkkwrykfdyivgnppyighkklekkykkfllekysevykdkadlyfcfykkiidilkqggigsvitpryfleslsgkdlreyiksnvnvqeivdflganifknigvssciltfdkkktketyidvfkiknedicinkfetleellksskfehfninqrllsdewilvnkddetfynkiqekckyslediaisfqgiitgcdkafilskddvklnlvddkflkcwikskninkyivdkseyrliysndidnentnkrildeiiglyktklenrrecksgIrkwyelqwgreklfferkkimypyksnenrfaidydnnfssadvysffikeeyldkfsyeylvgilnssvydkyfkitakkmskniydyypnkvmkirifrdnnyeeienlskqiisillnksidkgkveklqikmdnlimdslgi
interface signature	YNYHKDKYFNIVQISREIQWRYKSADYMSIY/I

Estimated binding specificities ?

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# IC=9.073 IC/col=1.134 n_of_columns=8

specificity:

A |  14   0   0   0   0   0   0  85
C |  52   0   0   0   0   0   0   5
G |  16   0   0   0   0   0  96   3
T |  14  96  96  96  96  96   0   3

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updated Sat Jun 27 05:58:28 2026