Estimated binding specificities ?

structure nameCAMA ADENINE METHYLTRANSFERASE COMPLEXED TO COGNATE SUBSTRATE DNA AND INHIBITOR N6-(2-PHENETHYL)ADENOSINE (COMPOUND 8)
(Site-specific DNA-methyltransferase adenine-specific)
referenceHorton et al. J.Med.Chem. 66 934 2023
sourceClostridioides difficile
experimentX-ray (resolution=2.19, R-factor=0.175)
structural superfamilyS-adenosyl-L-methionine-dependent methyltransferases;
sequence familyN6 DNA Methylase 1707;
multimeric complexes8cxs_AB 8cxt_AB 8cxu_AB 8cxv_AB 8cxw_AB 8cxx_AB 8cxy_AB 8cxz_AB 8cy0_AB 8cy1_AB 8cy2_AB 8cy3_AB 8cy4_AB 8cy5_AB 8fs1_AB 8fs2_AB
redundant complexes8cxs_C 8cxt_A 8cxu_C 8cxv_C 8cxw_A 8cxx_B 8cxz_B 8cy0_C 8cy1_B 8cy2_A 8cy3_B 8cy4_B 8cy5_A 8fs1_C 8fs2_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
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# IC=8.478 IC/col=1.060 n_of_columns=8 specificity:   
A |  21   0   0   0   0   0   0  42
C |  53   0   0   0   0   0   0  21
G |  22   0   0   0   0   0  96  10
T |   0  96  96  96  96  96   0  23
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updated Tue Jun 30 14:46:07 2026