8cxt_AB : 3D-footprint complex

structure name	CAMA ADENINE METHYLTRANSFERASE COMPLEXED TO COGNATE SUBSTRATE DNA AND INHIBITOR N6-BENZYLADENOSINE (COMPOUND 1)
reference	Horton et al. J.Med.Chem. 66 934 2023
source	Clostridioides difficile 630
experiment	X-ray (resolution=2.61, R-factor=?)
structural superfamily	S-adenosyl-L-methionine-dependent methyltransferases;
reference complex	8cxy_C
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 8cxt_A interface= sgiyytpkiivdyivkktlknhdiiknpyprildiscgcgnfllevydilydlfeeniyelkkkydenywtvdnihrhilnyciygadidekaisilkdsltnkkikinlfccdslkkkwrykfdyivgnppyighkklekkykkfllekysevykdkadlyfcfykkiidilkqggigsvitpryfleslsgkdlreyiksnvnvqeivdflganifknigvssciltfdkkktketyidvfkiknedicinkfetleellksskfehfninqrllsdewilvnkddetfynkiqekckyslediaisfqgiitgcdkafilskddvklnlvddkflkcwikskninkyivdkseyrliysndidnentnkrildeiiglyktklenrrecksgirkwyelqwgreklfferkkimypyksnenrfaidydnnfssadvysffikeeyldkfsyeylvgilnssvydkyfkitakkmskniydyypnkvmkirifrdnnyeeienlskqiisillnksidkgkveklqikmdnlimdslgi > 8cxt_B interface=3,138,141,144,145,165,166,194,226,229,231,319,322,352,398,399,404,411,412,414,428,429,445,446,447,449,486,487,490,494, giYytpkiivdyivkktlknhdiiknpyprildiscgcgnfllevydilydlfeeniyelkkkydenywtvdnihrhilnyciygadidekaisilkdsltnkkvvndldesdikinlfccdslkkkwrykfdyivgNppYigHKklekkykkfllekysevykDKadlyfcfykkiidilkqggigsvitprYfleslsgkdlreyiksnvnvqeivdflganiFknIgVssciltfdkkktketyidvfkiknedicinkfetleellksskfehfninqrllsdewilvnkddetfynkiqekckyslediaisfQgiItgcdkafilskddvklnlvddkflkcwikSkninkyivdkseyrliysndidnentnkrildeiiglyktklenrREcksgIrkwyelQWgReklfferkkimypYKsnenrfaidydnnfsSADvYsffikeeyldkfsyeylvgilnssvydkyfkitakkMSknIydyYpnkvmkirifrdnnyeeienlskqiisillnksidkgkveklqikmdnlimdslgi
interface signature	/YNYHKDKYFIVQISREIQWRYKSADYMSIY

Estimated binding specificities ?

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# IC=9.036 IC/col=1.129 n_of_columns=8

specificity:

A |  15   0   0   0   0   0   0  85
C |  49   0   0   0   0   0   0   3
G |  15   0   0   0   0   0  96   5
T |  17  96  96  96  96  96   0   3

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updated Sat Jun 27 05:59:11 2026