8cxw_AB : 3D-footprint complex

structure name	CAMA ADENINE METHYLTRANSFERASE COMPLEXED TO COGNATE SUBSTRATE DNA AND INHIBITOR PICLIDENOSON (COMPOUND 4)
reference	Horton et al. J.Med.Chem. 66 934 2023
source	Clostridioides difficile 630
experiment	X-ray (resolution=2.78, R-factor=?)
structural superfamily	S-adenosyl-L-methionine-dependent methyltransferases;
reference complex	8cxy_C
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 8cxw_A interface=1,131,134,137,138,158,159,187,219,221,222,224,312,315,345,391,392,397,404,405,407,421,422,438,439,440,442,479,480,483,487, YytpkiivdyivkktlknhdiiknpyprildiscgcgnfllevydilydlfeeniyelkkkydenywtvdnihrhilnyciygadidekaisilkdsltnkkdesdikinlfccdslkkkwrykfdyivgNppYigHKklekkykkfllekysevykDKadlyfcfykkiidilkqggigsvitprYfleslsgkdlreyiksnvnvqeivdflganiFkNIgVssciltfdkkktketyidvfkiknedicinkfetleellksskfehfninqrllsdewilvnkddetfynkiqekckyslediaisfQgiItgcdkafilskddvklnlvddkflkcwikSkninkyivdkseyrliysndidnentnkrildeiiglyktklenrREcksgIrkwyelQWgReklfferkkimypYKsnenrfaidydnnfsSADvYsffikeeyldkfsyeylvgilnssvydkyfkitakkMSknIydyYpnkvmkirifrdnnyeeienlskqiisillnksidkgkveklqikmdnlimdslgi > 8cxw_B interface=403, iyytpkiivdyivkktlknhdiiknpyprildiscgcgnfllevydilydlfeeniyelkkkydenywtvdnihrhilnyciygadidekaisilkdsltnkkvvndldesdikinlfccdslkkkwrykfdyivgnppyighkklekkykkfllekysevykdkadlyfcfykkiidilkqggigsvitpryfleslsgkdlreyiksnvnvqeivdflganifknigvssciltfdkkktketyidvfkiknedicinkfetleellksskfehfninqrllsdewilvnkddetfynkiqekckyslediaisfqgiitgcdkafilskddvklnlvddkflkcwikskninkyivdkseyrliysndidnentnkrildeiiglyktklenrrecksgIrkwyelqwgreklfferkkimypyksnenrfaidydnnfssadvysffikeeyldkfsyeylvgilnssvydkyfkitakkmskniydyypnkvmkirifrdnnyeeienlskqiisillnksidkgkveklqikmdnlimdslgi
interface signature	YNYHKDKYFNIVQISREIQWRYKSADYMSIY/I

Estimated binding specificities ?

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# IC=10.669 IC/col=0.821 n_of_columns=13

specificity:

A |  11   0   0  96  96  96  96  96   9  24  24  24   9
C |   9   0  96   0   0   0   0   0   9  24  24  24  69
G |   9   0   0   0   0   0   0   0  67  24  24  24   9
T |  67  96   0   0   0   0   0   0  11  24  24  24   9

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updated Sat Jun 27 06:00:55 2026