8cxz_AB : 3D-footprint complex

structure name	CAMA ADENINE METHYLTRANSFERASE COMPLEXED TO COGNATE SUBSTRATE DNA AND INHIBITOR N6-(3-PHENYLPROPYL)ADENOSINE (COMPOUND 14)
reference	Horton et al. J.Med.Chem. 66 934 2023
source	Clostridioides difficile
experiment	X-ray (resolution=2.35, R-factor=?)
structural superfamily	S-adenosyl-L-methionine-dependent methyltransferases;
reference complex	8cxy_C
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 8cxz_A interface=3,134,137,140,141,161,162,190,222,224,225,227,315,318,348,394,395,400,407,408,410,424,425,441,442,443,445,482,483,486,490, giYytpkiivdyivkktlknhdiiknpyprildiscgcgnfllevydilydlfeeniyelkkkydenywtvdnihrhilnyciygadidekaisilkdsltnkkvdesdikinlfccdslkkkwrykfdyivgNppYigHKklekkykkfllekysevykDKadlyfcfykkiidilkqggigsvitprYfleslsgkdlreyiksnvnvqeivdflganiFkNIgVssciltfdkkktketyidvfkiknedicinkfetleellksskfehfninqrllsdewilvnkddetfynkiqekckyslediaisfQgiItgcdkafilskddvklnlvddkflkcwikSkninkyivdkseyrliysndidnentnkrildeiiglyktklenrREcksgIrkwyelQWgReklfferkkimypYKsnenrfaidydnnfsSADvYsffikeeyldkfsyeylvgilnssvydkyfkitakkMSknIydyYpnkvmkirifrdnnyeeienlskqiisillnksidkgkveklqikmdnlimdslgi > 8cxz_B interface=404, giyytpkiivdyivkktlknhdiiknpyprildiscgcgnfllevydilydlfeeniyelkkkydenywtvdnihrhilnyciygadidekaisilkdsltnkkvvndldesdikinlfccdslkkkwrykfdyivgnppyighkklekkykkfllekysevykdkadlyfcfykkiidilkqggigsvitpryfleslsgkdlreyiksnvnvqeivdflganifknigvssciltfdkkktketyidvfkiknedicinkfetleellksskfehfninqrllsdewilvnkddetfynkiqekckyslediaisfqgiitgcdkafilskddvklnlvddkflkcwikskninkyivdkseyrliysndidnentnkrildeiiglyktklenrrecksgIrkwyelqwgreklfferkkimypyksnenrfaidydnnfssadvysffikeeyldkfsyeylvgilnssvydkyfkitakkmskniydyypnkvmkirifrdnnyeeienlskqiisillnksidkgkveklqikmdnlimdslgi
interface signature	YNYHKDKYFNIVQISREIQWRYKSADYMSIY/I

Estimated binding specificities ?

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# IC=9.127 IC/col=1.141 n_of_columns=8

specificity:

A |   3   0  96  96  96  96  96  13
C |   3  96   0   0   0   0   0  14
G |   5   0   0   0   0   0   0  56
T |  85   0   0   0   0   0   0  13

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updated Sat Jun 27 06:02:30 2026