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structure nameISORETICULAR, INTERPENETRATING CO-CRYSTAL OF REPLICATION INITIATOR PROTEIN REPE54 AND SYMMETRICAL EXPANDED DUPLEX (31MER) CONTAINING THE COGNATE REPE54 SEQUENCE AND AN ADDITIONAL G-C RICH SEQUENCE CO- CRYSTALLIZED WITH A GUEST SMALL MOLECULE, NETROPSIN.
(Replication initiation protein)
referenceOrun et al.
sourceEscherichia coli K-12
experimentX-ray (resolution=3.12, R-factor=0.197)
structural superfamily"Winged helix" DNA-binding domain;
sequence familyInitiator Replication protein;
multimeric complexes2z9o_AB
reference complex8ac8_C
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureSAESKRRSYRPDRRR

Estimated binding specificities ?

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# IC=14.276 IC/col=0.680 n_of_columns=21 specificity:   
A |  65  11  24   7   0   0   0  96   0  96  24  24  24  24   7   0   3  24  24   7  92
C |   9  59  24  13   0   0   0   0  96   0  24  24  24  24   6  96  93  24  24  76   0
G |  11  15  24   7  96   0  96   0   0   0  24  24  24  24  80   0   0  24  24  10   4
T |  11  11  24  69   0  96   0   0   0   0  24  24  24  24   3   0   0  24  24   3   0
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updated Fri Jan 9 21:18:07 2026