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structure nameISORETICULAR, INTERPENETRATING CO-CRYSTAL OF REPLICATION INITIATOR PROTEIN REPE54 AND SYMMETRICAL EXPANDED DUPLEX (31MER) CONTAINING THE COGNATE REPE54 SEQUENCE AND AN ADDITIONAL G-C RICH SEQUENCE CO- CRYSTALLIZED WITH A GUEST SMALL MOLECULE, NETROPSIN.
(Replication initiation protein)
referenceOrun et al.
sourceEscherichia coli K-12
experimentX-ray (resolution=3.12, R-factor=0.197)
structural superfamily"Winged helix" DNA-binding domain;
sequence familyInitiator Replication protein;
multimeric complexes2z9o_AB
reference complex7rva_C
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureSAESKRRSYRPDRRR

Estimated binding specificities ?

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# IC=5.191 IC/col=0.179 n_of_columns=29 specificity:   
A |  24  24  24  24  21  19  17  34  21  18  10  20  24  24  24  24   7   9   6   7  93   8  48  24  18  16  24  24  24
C |  24  24  24  24  31  16  15  22  21  18  10  38  24  24  24  24   8  11   6  75   1  70  16  24  18  19  24  24  24
G |  24  24  24  24  21  16  49  20  33  42  66  19  24  24  24  24   7  67   6   7   1   8  16  24  42  16  24  24  24
T |  24  24  24  24  23  45  15  20  21  18  10  19  24  24  24  24  74   9  78   7   1  10  16  24  18  45  24  24  24
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updated Tue Dec 19 02:40:55 2023