8ek8_EF : 3D-footprint complex

structure name	HUMAN PU.1 ETS-DOMAIN (165-270) BOUND TO D(AATAAAAGGAGAAGGG)
reference	Terrell et al. 'Cell 42 112671 2023
source	Homo sapiens
experiment	X-ray (resolution=2.63, R-factor=?)
structural superfamily	"Winged helix" DNA-binding domain;
reference complex	8ee9_F
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 8ek8_E interface=58,59,62,63,65,66, kirlyqflldllrsgdmkdsiwwvdkdkgtfqfsskhkealahrwgiqkgnrkkmtyQKmaRAlRNygktgevkkvkkkltyqfsgevlg > 8ek8_F interface=59,62,63,65,66, kirlyqflldllrsgdmkdsiwwvdkdkgtfqfsskhkealahrwgiqkgnrkkmtyqKmaRAlRNygktgevkkvkkkltyqfsgevlg
interface signature	QKRARN/KRARN

Estimated binding specificities ?

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# IC=9.730 IC/col=0.572 n_of_columns=17

specificity:

A |  15   0  81   0  96  24  24  24  15   6  24  24  24   9   0   0   6
C |   6   0   0   0   0  24  24  24  48  45  24  24  24   9  96  12  84
G |  72  96  15  96   0  24  24  24  24  36  24  24  24   3   0   0   3
T |   3   0   0   0   0  24  24  24   9   9  24  24  24  75   0  84   3

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updated Fri Aug 1 07:32:53 2025