8ek8_EF : 3D-footprint complex

structure name	HUMAN PU.1 ETS-DOMAIN (165-270) BOUND TO D(AATAAAAGGAGAAGGG)
reference	Terrell et al. 'Cell 42 112671 2023
source	Homo sapiens
experiment	X-ray (resolution=2.63, R-factor=?)
structural superfamily	"Winged helix" DNA-binding domain;
reference complex	8ee9_F
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 8ek8_E interface=58,59,62,63,65,66, kirlyqflldllrsgdmkdsiwwvdkdkgtfqfsskhkealahrwgiqkgnrkkmtyQKmaRAlRNygktgevkkvkkkltyqfsgevlg > 8ek8_F interface=59,62,63,65,66, kirlyqflldllrsgdmkdsiwwvdkdkgtfqfsskhkealahrwgiqkgnrkkmtyqKmaRAlRNygktgevkkvkkkltyqfsgevlg
interface signature	QKRARN/KRARN

Estimated binding specificities ?

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# IC=10.038 IC/col=0.590 n_of_columns=17

specificity:

A |  12   0  69   0  96  24  24  24   4   7  24  24  24   7   0   0   7
C |   7   0   0   0   0  24  24  24  34  56  24  24  24   4  96   7  83
G |  76  96  27  96   0  24  24  24  41  26  24  24  24   4   0   0   6
T |   1   0   0   0   0  24  24  24  17   7  24  24  24  81   0  89   0

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updated Wed Sep 11 23:20:15 2024