8ek8_EF : 3D-footprint complex

structure name	HUMAN PU.1 ETS-DOMAIN (165-270) BOUND TO D(AATAAAAGGAGAAGGG)
reference	Terrell et al. 'Cell 42 112671 2023
source	Homo sapiens
experiment	X-ray (resolution=2.63, R-factor=?)
structural superfamily	"Winged helix" DNA-binding domain;
reference complex	8ee9_F
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 8ek8_E interface=58,59,62,63,65,66, kirlyqflldllrsgdmkdsiwwvdkdkgtfqfsskhkealahrwgiqkgnrkkmtyQKmaRAlRNygktgevkkvkkkltyqfsgevlg > 8ek8_F interface=59,62,63,65,66, kirlyqflldllrsgdmkdsiwwvdkdkgtfqfsskhkealahrwgiqkgnrkkmtyqKmaRAlRNygktgevkkvkkkltyqfsgevlg
interface signature	QKRARN/KRARN

Estimated binding specificities ?

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# IC=10.200 IC/col=0.600 n_of_columns=17

specificity:

A |   0  80   0  85  24  24  24   2  11  24  24  24   2   0   1   0   2
C |   2   0   0   2  24  24  24  72  50  24  24  24   2  96  10  96  62
G |  92  15  96   5  24  24  24  20  25  24  24  24   4   0   0   0   7
T |   2   1   0   4  24  24  24   2  10  24  24  24  88   0  85   0  25

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updated Wed Jan 7 22:23:41 2026