8ek8_EF : 3D-footprint complex

structure name	HUMAN PU.1 ETS-DOMAIN (165-270) BOUND TO D(AATAAAAGGAGAAGGG)
reference	Terrell et al. 'Cell 42 112671 2023
source	Homo sapiens
experiment	X-ray (resolution=2.63, R-factor=?)
structural superfamily	"Winged helix" DNA-binding domain;
reference complex	8ee9_F
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 8ek8_E interface=58,59,62,63,65,66, kirlyqflldllrsgdmkdsiwwvdkdkgtfqfsskhkealahrwgiqkgnrkkmtyQKmaRAlRNygktgevkkvkkkltyqfsgevlg > 8ek8_F interface=59,62,63,65,66, kirlyqflldllrsgdmkdsiwwvdkdkgtfqfsskhkealahrwgiqkgnrkkmtyqKmaRAlRNygktgevkkvkkkltyqfsgevlg
interface signature	QKRARN/KRARN

Estimated binding specificities ?

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# IC=10.167 IC/col=0.598 n_of_columns=17

specificity:

A |   1  75   0  86  24  24  24   7   4  24  24  24   2   0   0   0   5
C |   2   1   0   4  24  24  24  64  54  24  24  24   2  96  16  96  60
G |  91  20  96   2  24  24  24  25  31  24  24  24   2   0   0   0   2
T |   2   0   0   4  24  24  24   0   7  24  24  24  90   0  80   0  29

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updated Mon Dec 16 00:53:03 2024