interface graph thumbnail
legend  pdf

structure nameHUMAN PU.1 ETS-DOMAIN (165-270) BOUND TO D(AATAAAAGGAATGGGG)
(Transcription factor PU.1)
referenceTerrell et al. 'Cell 42 112671 2023
sourceHomo sapiens
experimentX-ray (resolution=1.22, R-factor=0.144)
structural superfamily"Winged helix" DNA-binding domain;
sequence familyEtsdomain;
multimeric complexes8ek8_EF
redundant complexes1pue_E 8e3k_F 8e3r_F 8e4h_F 8e5y_F 8ebh_F 8ej6_F 8ej8_F 8ek3_F 8ek8_E 8ekj_F 8eku_F 8ekv_F 8ekz_F 8em9_F 8emd_F 8eng_F 8eo1_F 8eo4_F 8eqg_F 8eqk_F 8eql_F 8t9u_F
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureQKRARN

Estimated binding specificities ?

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# IC=3.457 IC/col=0.864 n_of_columns=4 specificity:   
A |  74   0   4  81
C |   7   0   4   7
G |   7  96  81   4
T |   8   0   7   4
scan!

Dendrogram of similar interfaces ?

matrix format
  
  --KT--RG----RGYA------   L                               +-4l18_B    
                                                    +------1 
  --KT--RG----RGYT------   L   +--------------------2      +-4bqa_A    
                               !                    ! 
  ECKT--RGAT--RGHT----RA   L --3                    +--------4mhg_A    
                               ! 
  ----NAST--RGHT--STLT--   L   +-----------------------------2c6y_A    
                             

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updated Sat Sep 14 09:50:58 2024