8gcc_AB : 3D-footprint complex

structure name	T. CRUZI TOPOISOMERASE II ALPHA BOUND TO DSDNA AND THE COVALENT INHIBITOR CT1
experiment	NMR
structural superfamily	Type II DNA topoisomerase;
reference complex	8gcc_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 8gcc_A interface=52,54,264,407,412, lgipklddaneaggkyshrctliltegdsakalctaglavkdrdyfgvfplRgKplnvrdatlkkvmacaefqavskimgldirqkysgverlryghlmimsdqdhdgshikgliinmihhywpdliktpgflqqfitpivkarisffsmpdyfewknaigdgirnyeiryykglgtsgakegreyfenidrhrldfvhedatddarivmafakdkveerkhwitqfkantnvnesmnynvrtvrysefvdkelilfsvadceRsipsvidglkpgqrkiifssfkrrltrsikvvqlagyvsehaayhhgeqslvqtivglaqnfvgsnnvpllqqdgqfgtrlqggkdhaagryiftrltniaryiyhpsddfvvdykdddglsvepfyyvpvipmvlvngtsgIgtgfAtnipnysplevidnlmrllrgeevqpmkpwyfgfagtieekekgkfvstgcanvrpdgvvqitelpigtwtqgykkfleelrekevvvqyrehntdvtvdfevflhpevlhhwvaqgcveerlqlreyihatniiafdregqitkyrdaeavlkefylvrleyyakrrdfligdlrsvasklenmvrfvtevvdgrlivtrrrkkelleelrqrgyapfpemrraardydyllgmrlwnltaemiarlqsqlqkardelaalekrtpkdlwaedlnqlrprienlfeerakeias > 8gcc_B interface=52,54,264,407, lgipklddaneaggkyshrctliltegdsakalctaglavkdrdyfgvfplRgKplnvrdatlkkvmacaefqavskimgldirqkysgverlryghlmimsdqdhdgshikgliinmihhywpdliktpgflqqfitpivkarisffsmpdyfewknaigdgirnyeiryykglgtsgakegreyfenidrhrldfvhedatddarivmafakdkveerkhwitqfkantnvnesmnynvrtvrysefvdkelilfsvadceRsipsvidglkpgqrkiifssfkrrltrsikvvqlagyvsehaayhhgeqslvqtivglaqnfvgsnnvpllqqdgqfgtrlqggkdhaagryiftrltniaryiyhpsddfvvdykdddglsvepfyyvpvipmvlvngtsgIgtgfatnipnysplevidnlmrllrgeevqpmkpwyfgfagtieekekgkfvstgcanvrpdgvvqitelpigtwtqgykkfleelrekevvvqyrehntdvtvdfevflhpevlhhwvaqgcveerlqlreyihatniiafdregqitkyrdaeavlkefylvrleyyakrrdfligdlrsvasklenmvrfvtevvdgrlivtrrrkkelleelrqrgyapfpemrraardydyllgmrlwnltaemiarlqsqlqkardelaalekrtpkdlwaedlnqlrprienlfeerakeias
interface signature	RKRIA/RKRI

Estimated binding specificities ?

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# IC=12.604 IC/col=0.900 n_of_columns=14

specificity:

A |   0  96  86   7  24  96   9   4   0  24  81   4   0   0
C |  96   0   0   4  24   0   0  72   0  24   4   4   0   0
G |   0   0   6   4  24   0  76  11   0  24   7   4   0  96
T |   0   0   4  81  24   0  11   9  96  24   4  84  96   0

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updated Sat Jun 27 10:55:52 2026