interface graph thumbnail
legend  pdf

structure nameTWIST1-TCF4-ALX4 COMPLEX ON SPECIFIC DNA
referenceMorgunova et al. Cell 187 692 2024
experimentX-ray (resolution=2.90, R-factor=0.223)
structural superfamilyHLH, helix-loop-helix DNA-binding domain;
sequence familyHelixloophelix DNAbinding domain;
multimeric complexes8osb_ABE
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRNRER

Estimated binding specificities ?

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# IC=3.142 IC/col=0.786 n_of_columns=4 specificity:   
A |  13  57   0  96
C |  54  13  96   0
G |  16  13   0   0
T |  13  13   0   0
scan!

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updated Mon Aug 4 01:42:07 2025