8osb_ABE : 3D-footprint complex

structure name	TWIST1-TCF4-ALX4 COMPLEX ON SPECIFIC DNA
reference	Morgunova et al. Cell 187 692 2024
experiment	X-ray (resolution=2.90, R-factor=?)
structural superfamily	HLH, helix-loop-helix DNA-binding domain;Homeodomain-like;
reference complex	6od3_F 8osb_B 8osb_E
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 8osb_A interface=6,8,9,12,13, rrmanNaRErlRVrdineafkelgrmvqlhlksdkpqtkllilhqavavilsleqqvrer > 8osb_B interface=9,13,15,16,19, syeelqtqRvmaNvRErqRtqslneafaalrkiiptlpsdklskiqtlklaaryidflyqvlqsde > 8osb_E interface=3,44,45,48,49, rnRttftsyqleelekvfqkthypdvyareqlamrtdltearvQVwfQNrrakwrkrerfgq
interface signature	NRERV/RNRER/RQVQN

Estimated binding specificities ?

readout + contact

# IC=16.997 IC/col=0.895 n_of_columns=19

specificity:

A |   0  96   0  96  12  24   0   0   0   6  14  24   6  24  24   0   0  96   0
C |  96   0  96   0  12  24   0   0   0   6  12  24   8  24  24   0   0   0  96
G |   0   0   0   0   0  24   0  96  96   6   6  24   6  24  24   0   0   0   0
T |   0   0   0   0  72  24  96   0   0  78  64  24  76  24  24  96  96   0   0

scan!

home
updated Thu Jan 8 06:09:14 2026