8osb_ABE : 3D-footprint complex

structure name	TWIST1-TCF4-ALX4 COMPLEX ON SPECIFIC DNA
reference	Morgunova et al. Cell 187 692 2024
experiment	X-ray (resolution=2.90, R-factor=?)
structural superfamily	HLH, helix-loop-helix DNA-binding domain;Homeodomain-like;
reference complex	6od3_F 8osb_B 8osb_E
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 8osb_A interface=6,8,9,12,13, rrmanNaRErlRVrdineafkelgrmvqlhlksdkpqtkllilhqavavilsleqqvrer > 8osb_B interface=9,13,15,16,19, syeelqtqRvmaNvRErqRtqslneafaalrkiiptlpsdklskiqtlklaaryidflyqvlqsde > 8osb_E interface=3,44,45,48,49, rnRttftsyqleelekvfqkthypdvyareqlamrtdltearvQVwfQNrrakwrkrerfgq
interface signature	NRERV/RNRER/RQVQN

Estimated binding specificities ?

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# IC=17.476 IC/col=0.920 n_of_columns=19

specificity:

A |   0   0  96  96  24  24  84  65  67  82   0   0  96  24  61   0   0   0   0
C |   0   0   0   0  24  24   4   8  13   4  96  96   0  24  13   0   0   0   0
G |  96   0   0   0  24  24   4  10   8   4   0   0   0  24   9   0  96   0  96
T |   0  96   0   0  24  24   4  13   8   6   0   0   0  24  13  96   0  96   0

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updated Sat Jun 27 15:44:10 2026