8pi7_AB : 3D-footprint complex

structure name	DNA BINDING DOMAIN OF HNF-1A BOUND TO P2-HNF4A PROMOTER DNA VARIANT (P2 -169C>T)
reference	Myllykoski et al. 'JCI 9 ? 2024
source	Homo sapiens
experiment	X-ray (resolution=3.20, R-factor=?)
structural superfamily	lambda repressor-like DNA-binding domains;Homeodomain-like;
reference complex	8pi8_B
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 8pi7_A interface=51,52,53,54,56,57,63,94,156,161,164, enlspeeaahqkavvetllqedpwrvakmvksylqqhnipqrevvdttglNQSHlSQhlnkgTpmktqkraalytwyvrkqrevaqqfthagnRfkwgpasqqilfqayerqknpskeeretlveecnraeciqrgvspsqaqglgsnlvtevrvYnwfaNrrKeeaf > 8pi7_B interface=52,53,54,56,57,63,94,156,157,161,164, enlspeeaahqkavvetllqedpwrvakmvksylqqhnipqrevvdttglnQSHlSQhlnkgTpmktqkraalytwyvrkqrevaqqftharnRfkwgpasqqilfqayerqknpskeeretlveecnraeciqrgvspsqaqglgsnlvtevrvYNwfaNrrKeea
interface signature	NQSHSQTRYNK/QSHSQTRYNNK

Estimated binding specificities ?

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# IC=16.388 IC/col=0.964 n_of_columns=17

specificity:

A |   0  81   0   0  96   5   0   7  11   4   0  96  96   5  24  24  76
C |   0   4   0   0   0  91   0  81   0   7   1   0   0   0  24  24   4
G |  96   4   0   0   0   0   0   4   9   4   4   0   0   0  24  24   9
T |   0   7  96  96   0   0  96   4  76  81  91   0   0  91  24  24   7

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updated Thu Jan 8 07:07:13 2026