8pi7_AB : 3D-footprint complex

structure name	DNA BINDING DOMAIN OF HNF-1A BOUND TO P2-HNF4A PROMOTER DNA VARIANT (P2 -169C>T)
reference	Myllykoski et al. 'JCI 9 ? 2024
source	Homo sapiens
experiment	X-ray (resolution=3.20, R-factor=?)
structural superfamily	lambda repressor-like DNA-binding domains;Homeodomain-like;
reference complex	8pi8_B
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 8pi7_A interface=51,52,53,54,56,57,63,94,156,161,164, enlspeeaahqkavvetllqedpwrvakmvksylqqhnipqrevvdttglNQSHlSQhlnkgTpmktqkraalytwyvrkqrevaqqfthagnRfkwgpasqqilfqayerqknpskeeretlveecnraeciqrgvspsqaqglgsnlvtevrvYnwfaNrrKeeaf > 8pi7_B interface=52,53,54,56,57,63,94,156,157,161,164, enlspeeaahqkavvetllqedpwrvakmvksylqqhnipqrevvdttglnQSHlSQhlnkgTpmktqkraalytwyvrkqrevaqqftharnRfkwgpasqqilfqayerqknpskeeretlveecnraeciqrgvspsqaqglgsnlvtevrvYNwfaNrrKeea
interface signature	NQSHSQTRYNK/QSHSQTRYNNK

Estimated binding specificities ?

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# IC=16.432 IC/col=0.967 n_of_columns=17

specificity:

A |   0  80   0   0  96   6   0   5  10   5   0  96  96   6  24  24  75
C |   0   5   0   0   0  90   0  80   0   5   0   0   0   0  24  24   5
G |  96   6   0   0   0   0   0   5  11   5   0   0   0   0  24  24  11
T |   0   5  96  96   0   0  96   6  75  81  96   0   0  90  24  24   5

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updated Sat Jun 27 16:41:37 2026