8pi8_AB : 3D-footprint complex

structure name	DNA BINDING DOMAIN OF HNF-1A BOUND TO P2-HNF4A PROMOTER DNA
reference	Myllykoski et al. 'JCI 9 ? 2024
source	Homo sapiens
experiment	X-ray (resolution=2.30, R-factor=?)
structural superfamily	lambda repressor-like DNA-binding domains;Homeodomain-like;
reference complex	8pi8_B
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 8pi8_A interface=56,57,58,59,61,62,68,69,101,163,164,168,171, ilkelenlspeeaahqkavvetllqedpwrvakmvksylqqhnipqrevvdttglNQSHlSQhlnkgTPmktqkraalytwyvrkqrevaqqfthagrrnRfkwgpasqqilfqayerqknpskeeretlveecnraeciqrgvspsqaqglgsnlvtevrvYNwfaNrrKeea > 8pi8_B interface=49,50,51,52,54,55,61,62,91,153,154,158,161, lspeeaahqkavvetllqedpwrvakmvksylqqhnipqrevvdttglNQSHlSQhlnkgTPmktqkraalytwyvrkqrevaqqfthrnRfkwgpasqqilfqayerqknpskeeretlveecnraeciqrgvspsqaqglgsnlvtevrvYNwfaNrrKeea
interface signature	NQSHSQTPRYNNK/NQSHSQTPRYNNK

Estimated binding specificities ?

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# IC=20.036 IC/col=1.179 n_of_columns=17

specificity:

A |   9   9   9   0   0   0  96   0   0   0   0   0   0  96  96   0   0
C |  69   9   9   0   0   0   0  96   0  96   0   0   0   0   0  96   0
G |   9   9  67  96   0   0   0   0   0   0   0   0   0   0   0   0  96
T |   9  69  11   0  96  96   0   0  96   0  96  96  96   0   0   0   0

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updated Fri Aug 1 15:15:30 2025