8pi9_AB : 3D-footprint complex

structure name	DNA BINDING DOMAIN OF HNF-1A BOUND TO P2-HNF4A PROMOTER DNA VARIANT (P2 -181G>A)
reference	Myllykoski et al. 'JCI 9 ? 2024
source	Homo sapiens
experiment	X-ray (resolution=2.80, R-factor=?)
structural superfamily	lambda repressor-like DNA-binding domains;Homeodomain-like;
reference complex	8pi8_B
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 8pi9_A interface=48,49,50,51,53,54,60,92,154,155,159,162, speeaahqkavvetllqedpwrvakmvksylqqhnipqrevvdttglNQSHlSQhlnkgTpmktqkraalytwyvrkqrevaqqftharrnRfkwgpasqqilfqayerqknpskeeretlveecnraeciqrgvspsqaqglgsnlvtevrvYNwfaNrrKeea > 8pi9_B interface=57,58,59,60,62,63,69,104,166,171,174, pilkelenlspeeaahqkavvetllqedpwrvakmvksylqqhnipqrevvdttglNQSHlSQhlnkgTpmktqkraalytwyvrkqrevaqqfthagqggrnRfkwgpasqqilfqayerqknpskeeretlveecnraeciqrgvspsqaqglgsnlvtevrvYnwfaNrrKeea
interface signature	NQSHSQTRYNNK/NQSHSQTRYNK

Estimated binding specificities ?

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# IC=18.772 IC/col=0.988 n_of_columns=19

specificity:

A |   4  24   4  24   0   0  96  96  96   5  96   0   0  96  96   9   4  84  10
C |   4  24  83  24   0   0   0   0   0   4   0   0   0   0   0   8  83   4   8
G |   4  24   5  24   0   0   0   0   0  87   0  96   0   0   0   4   4   4  70
T |  84  24   4  24  96  96   0   0   0   0   0   0  96   0   0  75   5   4   8

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updated Fri Aug 1 15:15:48 2025