8pi9_AB : 3D-footprint complex

structure name	DNA BINDING DOMAIN OF HNF-1A BOUND TO P2-HNF4A PROMOTER DNA VARIANT (P2 -181G>A)
reference	Myllykoski et al. 'JCI 9 ? 2024
source	Homo sapiens
experiment	X-ray (resolution=2.80, R-factor=?)
structural superfamily	lambda repressor-like DNA-binding domains;Homeodomain-like;
reference complex	8pi8_B
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 8pi9_A interface=48,49,50,51,53,54,60,92,154,155,159,162, speeaahqkavvetllqedpwrvakmvksylqqhnipqrevvdttglNQSHlSQhlnkgTpmktqkraalytwyvrkqrevaqqftharrnRfkwgpasqqilfqayerqknpskeeretlveecnraeciqrgvspsqaqglgsnlvtevrvYNwfaNrrKeea > 8pi9_B interface=57,58,59,60,62,63,69,104,166,171,174, pilkelenlspeeaahqkavvetllqedpwrvakmvksylqqhnipqrevvdttglNQSHlSQhlnkgTpmktqkraalytwyvrkqrevaqqfthagqggrnRfkwgpasqqilfqayerqknpskeeretlveecnraeciqrgvspsqaqglgsnlvtevrvYnwfaNrrKeea
interface signature	NQSHSQTRYNNK/NQSHSQTRYNK

Estimated binding specificities ?

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# IC=19.134 IC/col=1.007 n_of_columns=19

specificity:

A |  11   0   4  72   0   0  96   0   0   0   0   0   0  96  96  24   4  24  81
C |  67   4   4   4   0   0   0  96   0  96   0   0   0   0   0  24   4  24   4
G |   9   4  84  11   0   0   0   0   0   0   0   0   0   0   0  24  84  24   4
T |   9  88   4   9  96  96   0   0  96   0  96  96  96   0   0  24   4  24   7

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updated Sat Jun 27 16:42:16 2026