8pi9_AB : 3D-footprint complex

structure name	DNA BINDING DOMAIN OF HNF-1A BOUND TO P2-HNF4A PROMOTER DNA VARIANT (P2 -181G>A)
reference	Myllykoski et al. 'JCI 9 ? 2024
source	Homo sapiens
experiment	X-ray (resolution=2.80, R-factor=?)
structural superfamily	lambda repressor-like DNA-binding domains;Homeodomain-like;
reference complex	8pi8_B
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 8pi9_A interface=48,49,50,51,53,54,60,92,154,155,159,162, speeaahqkavvetllqedpwrvakmvksylqqhnipqrevvdttglNQSHlSQhlnkgTpmktqkraalytwyvrkqrevaqqftharrnRfkwgpasqqilfqayerqknpskeeretlveecnraeciqrgvspsqaqglgsnlvtevrvYNwfaNrrKeea > 8pi9_B interface=57,58,59,60,62,63,69,104,166,171,174, pilkelenlspeeaahqkavvetllqedpwrvakmvksylqqhnipqrevvdttglNQSHlSQhlnkgTpmktqkraalytwyvrkqrevaqqfthagqggrnRfkwgpasqqilfqayerqknpskeeretlveecnraeciqrgvspsqaqglgsnlvtevrvYnwfaNrrKeea
interface signature	NQSHSQTRYNNK/NQSHSQTRYNK

Estimated binding specificities ?

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# IC=18.967 IC/col=0.998 n_of_columns=19

specificity:

A |   9   4   4  74   0   0  96   0   0   0   0   0   0  96  96  24   4  24  82
C |  69   6   6   4   0   0   0  96   0  96   0   0   0   0   0  24   4  24   4
G |   9   4  82   9   0   0   0   0   0   0   0   0   0   0   0  24  84  24   6
T |   9  82   4   9  96  96   0   0  96   0  96  96  96   0   0  24   4  24   4

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updated Thu Jan 8 07:07:46 2026