8pia_AB : 3D-footprint complex

structure name	DNA BINDING DOMAIN OF HNF-1A BOUND TO P2-HNF4A PROMOTER DNA VARIANT (P2 -181G>T)
reference	Myllykoski et al. 'JCI 9 ? 2024
source	Homo sapiens
experiment	X-ray (resolution=2.80, R-factor=?)
structural superfamily	lambda repressor-like DNA-binding domains;Homeodomain-like;
reference complex	8pi8_B
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 8pia_A interface=47,48,49,50,52,53,59,90,152,157,160, peeaahqkavvetllqedpwrvakmvksylqqhnipqrevvdttglNQSHlSQhlnkgTpmktqkraalytwyvrkqrevaqqftharnRfkwgpasqqilfqayerqknpskeeretlveecnraeciqrgvspsqaqglgsnlvtevrvYnwfaNrrKeea > 8pia_B interface=47,48,49,50,53,90,152,153,157,160, peeaahqkavvetllqedpwrvakmvksylqqhnipqrevvdttglNQSHlsQhlnkgtpmktqkraalytwyvrkqrevaqqftharnRfkwgpasqqilfqayerqknpskeeretlveecnraeciqrgvspsqaqglgsnlvtevrvYNwfaNrrKeea
interface signature	NQSHSQTRYNK/NQSHQRYNNK

Estimated binding specificities ?

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# IC=13.883 IC/col=0.926 n_of_columns=15

specificity:

A |  11  24   5   5   0   0  96   0   0  24  11   7   0  96  96
C |  63  24   5   0   0   0   0  96   0  24   7   5   0   0   0
G |  11  24  81   5   0   0   0   0   0  24  11   5   0   0   0
T |  11  24   5  86  96  96   0   0  96  24  67  79  96   0   0

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updated Sat Jun 27 16:42:39 2026