8pia_AB : 3D-footprint complex

structure name	DNA BINDING DOMAIN OF HNF-1A BOUND TO P2-HNF4A PROMOTER DNA VARIANT (P2 -181G>T)
reference	Myllykoski et al. 'JCI 9 ? 2024
source	Homo sapiens
experiment	X-ray (resolution=2.80, R-factor=?)
structural superfamily	lambda repressor-like DNA-binding domains;Homeodomain-like;
reference complex	8pi8_B
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 8pia_A interface=47,48,49,50,52,53,59,90,152,157,160, peeaahqkavvetllqedpwrvakmvksylqqhnipqrevvdttglNQSHlSQhlnkgTpmktqkraalytwyvrkqrevaqqftharnRfkwgpasqqilfqayerqknpskeeretlveecnraeciqrgvspsqaqglgsnlvtevrvYnwfaNrrKeea > 8pia_B interface=47,48,49,50,53,90,152,153,157,160, peeaahqkavvetllqedpwrvakmvksylqqhnipqrevvdttglNQSHlsQhlnkgtpmktqkraalytwyvrkqrevaqqftharnRfkwgpasqqilfqayerqknpskeeretlveecnraeciqrgvspsqaqglgsnlvtevrvYNwfaNrrKeea
interface signature	NQSHSQTRYNK/NQSHQRYNNK

Estimated binding specificities ?

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# IC=13.792 IC/col=0.919 n_of_columns=15

specificity:

A |   0   0  96  80  69  24  96   0   0  96  96  81   5  24  10
C |   0   0   0   5   5  24   0   0   0   0   0   5  81  24  12
G |   0   0   0   5  10  24   0  96   0   0   0   5   5  24  64
T |  96  96   0   6  12  24   0   0  96   0   0   5   5  24  10

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updated Thu Jan 8 07:08:03 2026