8tit_C : 3D-footprint complex

structure name	ISORETICULAR, INTERPENETRATING CO-CRYSTAL OF REPLICATION INITIATOR PROTEIN REPE54 AND SYMMETRICAL EXPANDED DUPLEX (31MER) CONTAINING THE COGNATE REPE54 SEQUENCE AND AN ADDITIONAL G-C RICH SEQUENCE WITH 2 STICKY BASE OVERHANGS AND NO TERMINAL PHOSPHATES. (Replication initiation protein)
reference	Slaughter et al.
source	Escherichia coli K-12
experiment	X-ray (resolution=2.84, R-factor=0.209)
structural superfamily	"Winged helix" DNA-binding domain;
sequence family	Initiator Replication protein;
multimeric complexes	2z9o_AB
reference complex	8ac8_C
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 8tit_C interface=54,55,56,58,59,62,92,162,163,165,167,168,171,172,198, sprivqsndlteaayslsrdqkrmlylfvdqirksdgiceihvakyaeifgltSAEaSKdiRqalksfagkevvfyyesfpwfikpahspsRglysvhinpylipffigrftqfrlsetkeitnpyamrlyeslcqyrkpdgsgivslkidwiieryqlpqSYqRmPDfrRRflqvcvneinsrtpmrlsyiekkkgRqtthivfsfrdi
interface signature	SAESKRRSYRPDRRR

Estimated binding specificities ?

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# IC=15.086 IC/col=0.718 n_of_columns=21

specificity:

A |   0   8  59  24   0   0   5  24  24  24  24   0   0   0   0  96   0  69  24   9   6
C |   2   3   7  24   0   0  48  24  24  24  24   0   0   0  96   0  96   9  24  17   3
G |   0  84  17  24  96  96  40  24  24  24  24   0  96   0   0   0   0   9  24  49   1
T |  94   1  13  24   0   0   3  24  24  24  24  96   0  96   0   0   0   9  24  21  86

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updated Sat Jan 10 02:13:02 2026