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structure nameISORETICULAR, INTERPENETRATING CO-CRYSTAL OF REPLICATION INITIATOR PROTEIN REPE54 AND SYMMETRICAL EXPANDED DUPLEX (31MER) CONTAINING THE COGNATE REPE54 SEQUENCE AND AN ADDITIONAL G-C RICH SEQUENCE WITH BLUNT ENDS AND 5' TERMINAL PHOSPHATES AND CROSSLINKED WITH EDC.
(Replication initiation protein)
referenceSlaughter et al.
sourceEscherichia coli K-12
experimentX-ray (resolution=3.35, R-factor=0.239)
structural superfamily"Winged helix" DNA-binding domain;
sequence familyInitiator Replication protein;
multimeric complexes2z9o_AB
reference complex8ac8_C
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureSESKRRSYRPDRRR

Estimated binding specificities ?

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# IC=14.292 IC/col=0.681 n_of_columns=21 specificity:   
A |  81   2  24   0   0   0   0  81   0  90  24  24  24  24   6  60   5  24  24   2  91
C |   2  81  24   4   0   0   0   7  96   2  24  24  24  24   2  26  91  24  24  86   0
G |   9   4  24   4  96   0  96   4   0   2  24  24  24  24  86   6   0  24  24   6   4
T |   4   9  24  88   0  96   0   4   0   2  24  24  24  24   2   4   0  24  24   2   1
scan!

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updated Sat Jan 10 02:13:54 2026