8tvy_ABEM : 3D-footprint complex

structure name	CRYO-EM STRUCTURE OF CPD LESION CONTAINING RNA POLYMERASE II ELONGATION COMPLEX WITH RAD26 AND ELF1 (CLOSED STATE)
experiment	NMR
structural superfamily	P-loop containing nucleoside triphosphate hydrolases;
reference complex	8tvy_M
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 8tvy_A interface=36,37,245,246,249,310,343,440,441,824,1379, saplrtvkevqfglfspeevraisvakirfpetmdETqtrakigglndprlgsidrnlkcqtcqegmnecpghfghidlakpvfhvgfiakikkvcecvcmhcgkllldehnelmrqalaikdskkrfaaiwtlcktkmvcetdvpseddptqlvsrggcgntqptirkdglklvgswkkdratgdadepelrvlsteeilnifkhisvkdftslgfnevfsrpewmiltclpvppppvrpsisFNesQrgeddltfkladilkanisletlehngaphhaieeaesllqfhvatymdndiagqpqalqKsgrpvksirarlkgkegrirgnlmgkrvdfsaRtvisgdpnleldqvgvpksiaktltypevvtpynidrltqlvrngpnehpgakyvirdsgdridlryskragdiqlqygwkverhimdndpvlfnrQPslhkmsmmahrvkvipystfrlnlsvtspynadfdgdemnlhvpqseetraelsqlcavplqivspqsnkpcmgivqdtlcgirkltlrdtfieldqvlnmlywvpdwdgviptpaiikpkplwsgkqilsvaipngihlqrfdegttllspkdngmliidgqiifgvvekktvgssngglihvvtrekgpqvcaklfgniqkvvnfwllhngfstgigdtiadgptmreitetiaeakkkvldvtkeaqanlltakhgmtlresfednvvrflneardkagrlaevnlkdlnnvkqmvmagskgsfiniaqmsacvgqqsvegkriafgfvdrtlphfskddyspeskgfvensylrgltpqefffhamggreglidtavkTaetgyiqrrlvkaledimvhydnttrnslgnviqfiygedgmdaahiekqsldtiggsdaafekryrvdllntdhtldpsllesgseilgdlklqvlldeeykqlvkdrkflrevfvdgeanwplpvnirriiqnaqqtfhidhtkpsdltikdivlgvkdlqenllvlrgkneiiqnaqrdavtlfccllrsrlatrrvlqeyrltkqafdwvlsnieaqflrsvvhpgemvgvlaaqsigepatqmtlntfhfagvaskkvtsgvprlkeilnvaknmktpsltvylepghaadqeqaklirsaiehttlksvtiaseiyydpdprstvipedeeiiqlhfslldeeaeqsfdqqspwllrleldraamndkdltmgqvgerikqtfkndlfviwsedndekliircrvvrpksldaeteaeedhmlkkientmlenitlrgveniervvmmkydrkvpsptgeyvkepewvletdgvnlsevmtvpgidptriytnsfidimevlgieagraalykevynviasdgsyvnyrhmallvdvmttqggltsvtRhgfnrsntgalmrcsfeetveilfeagasaelddcrgvsenvilgqmapigtgafdvmideeslvkymp > 8tvy_B interface=413,453,456,457,459,484,848,849, fedesapitaedswavisaffrekglvsqqldsfnqfvdytlqdiicedstlileqlaqhttesdnisrkyeisfgkiyvtkpmvnesdgvthalypqearlrnltyssglfvdvkkrtyeaidvpgrelkyeliaeeseddsesgkvfigrlpimlrskncylseatesdlyklkecpfdmggyfiingsekvliaqersagnivqvfkkaapspishvaeirsalekgsrfistlqvklygregssartikatlpyikqdipiviifralgiipdgeilehicydvndwqmlemlkpcvedgfviqdretaldfigrrgtalgikkekriqyakdilqkeflphitqlegfesrkafflgyminrlllcaldrkdqddrdhfgkkrldlagpllaqlfktlfkkltkdifRymqrtveeahdfnmklainaktitsglkyalatgnwgeqKkaMSsRagvsqvlnrytysstlshlrrtntPigrdgklakprqlhnthwglvcpaetpegqacglvknlslmscisvgtdpmpiitflsewgmepledyvphqspdatrvfvngvwhgvhrnparlmetlrtlrrkgdinpevsmirdirekelkiftdagrvyrplfiveddeslghkelkvrkghiaklmateyqdieggfedveeytwssllneglveyidaeeeesiliamqpedlepaeaneendldvdpakrirvshhattfthceihpsmilgvaasiipfpdhnqsprntyqsamgkqamgvfltnynvrmdtmanilyypqkplgttrameylkfrelpagqnaivaiacysgynqedsmimnqssidrglfrslffrsymdqekKYgmsitetfekpqrtntlrmkhgtydkldddgliapgvrvsgedviigkttpispdeeelgqrtayhskrdastplrstengivdqvlvttnqdglkfvkvrvrttkipqigdkfasrhgqkgtigityrredmpftaegivpdliinphaipsrmtvahliecllskvaalsgnegdaspftditvegiskllrehgyqsrgfevmynghtgkklmaqiffgptyyqrlrhmvddkiharargpmqvltrqpvegrsrdgglrfgemerdcmiahgaasflkerlmeasdafrvhicgicglmtviaklnhnqfeckgcdnkidiyqihipyaakllfqelmamnitprlytdrsrdf > 8tvy_E interface= mdqenernisrlwrafrtvkemvkdrgyfitqeevelpledfkakycdsmgrpqrkmmsfqanpteesiskfpdmgslwvefcdepsvgvktmktfvihiqeknfqtgifvyqnnitpsamklvpsippatietfneaalvvnithhelvpkhirlssdekrellkryrlkesqlpriqradpvalylglkrgevvkiirksetsgryasyricm > 8tvy_M interface=213,214,215,270,345,346,348,466,554, ddeeeenddkilkeledlrfrgqpgeakddgdelyyqerlkkwvkqrscgsqrssdlpewrrphpnipdaklnsqfkipgeiysllfnyqktcvqwlyelyqqncggiigdemglgktiqviafiaalhhsglltgpvlivcpatvmkqwcnefqhwwpplrtvilhsmgsgmasdhilittyvglrihsdkllkvkwqyavldeghkirnpDSEisltckklkthnriilsgtpiqnnltelwslfdfifpgklgtlpvfqqqfvipiNiggyanatniqvqtgykcavalrdlispyllrrvkadvakdlpqkkemvlfckltkyqrskyleflhssdlnqiQNgKrnvlfgidilrkicnhpdlldrdtkrhnpdygdpkrsgkmqvvkqllllwhkqgykallftqsrqmldileefistkdpdlshlnylrmdgttnikgrqslvdrfnnesfdvfllttRvgglgvnltganriiifdpdwnpstdmqarerawrigqkrevsiyrlmvggsieekiyhrqifkqfltnriltdpkqkrffkihelhDlfsl
interface signature	ETFNQKRQPTR/RKMSRPKY//DSENQNKRD

Estimated binding specificities ?

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# IC=12.477 IC/col=0.734 n_of_columns=17

specificity:

A |   3  84  24  87   0   0  96   0  24  24  24  24  84   6   3   3  87
C |  84   3  24   3   0  96   0   0  24  24  24  24   3  84   3  84   3
G |   6   6  24   3   0   0   0   0  24  24  24  24   6   3   3   6   3
T |   3   3  24   3  96   0   0  96  24  24  24  24   3   3  87   3   3

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updated Thu Jan 8 11:13:16 2026