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structure nameANTENNAPEDIA HOMEODOMAIN-DNA COMPLEX
(ANTENNAPEDIA HOMEODOMAIN)
referenceFraenkel et al. Nat.Struct.Biol. 5 692 1998
sourceDrosophila melanogaster
experimentX-ray (resolution=2.40, R-factor=0.218)
structural superfamilyHomeodomain-like;
sequence familyHomeobox domain;
redundant complexes4xic 4xid 5jlw 5jlx
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRKIQNM

Estimated binding specificities ?

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# IC=6.292 IC/col=0.899 n_of_columns=7 specificity:   
A |   7   7  96   0   7  96   7
C |  73   9   0   0   7   0   9
G |   9   7   0   0   7   0  73
T |   7  73   0  96  75   0   7
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: ANTENNAPEDIA
TATAAPubMed9ant_B(6.65e-03)
TTAATTPubMed9ant_B(3.38e-03), 4xid_A(3.37e-03), 4xic_A(1.13e-03)

Dendrogram of similar interfaces ?

matrix format
  
  --------------------------IA--QCNAMG----   L                                  +2r5z_A    
                                                                              +-1 
  --------------------------IA--QTNA----KT   L                                ! +4rdu_A    
                                                                      +-------4 
  --------------------------IA----NA------                            !       ! +4qtr_D    
                                                                      !       +-2 
  --------------------------IA----NA------                         +--8         +4xrs_G    
                                                                   !  ! 
  --------------------------IA--QTNAMC----   L                     !  !        +--2h1k_B    
                                                                   !  !      +-5 
  --------------------------NC--ICRG------   L                  +--9  +------6 +--4xrm_B    
                                                                !  !         ! 
  RT------------------------NT----NAIARG--   L                  !  !         +--4cyc_B    
                                                                !  ! 
  --------------------------TA--QCNAMC----                   +-10  !           +4rbo_D    
                                                             !  !  +-----------3 
  NGRGTG--------LC----LCRG----------------                   !  !              +4ofa_A    
                                                          +-11  !  
  --KA------------SG--AT--YTRG------------   L            !  !  +---------------4rb3_D    
                                                          !  !  
  --------------------------IA--QCNAMC----   L      +----12  !         +--------4cyc_A    
                                                    !     !  +---------7 
  --------IGYGFG--------------------------          !     !            +--------4ztu_A    
                                                 +-13     !  
  --------------------NTVCECSTYTSTYC------   L   !  !     +---------------------5ed4_A    
                                               -14  !  
  --QGTGRA--------YC----RG----------------       !  +---------------------------3fsp_A    
                                                 !  
  ----------------TGKG--------------------   L   +-----------------------------4pxi_B    
                                               

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updated Tue Dec 17 21:40:08 2024