1a1h_A : 3D-footprint complex

structure name	QGSR (ZIF268 VARIANT) ZINC FINGER-DNA COMPLEX (GCAC SITE) (QGSR ZINC FINGER PEPTIDE)
reference	Elrod-Erickson et al.
source	Mus musculus
experiment	X-ray (resolution=1.60, R-factor=0.235)
structural superfamily	C2H2 and C2HC zinc fingers;
sequence family	Zinc finger, C2H2 type;
multimeric complexes	1p47_AB
redundant complexes	1zaa 1a1g 1a1k 1jk1 1a1l 1a1i 1p47 1a1j 1a1f 1aay 1jk2
reference complex	4x9j_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 1a1h_A interface=16,19,22,44,45,46,47,50,72,74,75,78, rpyacpvescdrrfsQsgSltRhirihtgqkpfqcricmrnfsRSDHltThirthtgekpfacdicgrkfaRsDErkRhtkihlr
interface signature	QSRRSDHTRDER

Estimated binding specificities ?

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# IC=9.580 IC/col=1.064 n_of_columns=9

specificity:

A |   0   0   0  12  12   0   0  12  96
C |   0  96   0  12   0   0   0  60   0
G |  96   0  96  12  84  96  96  12   0
T |   0   0   0  60   0   0   0  12   0

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Related DNA sequences reported in the literature ?

site	source	matches (E-value)
term: ZIF268
GCGTGGGGCG	PubMed	1a1h_A(9.86e-08), 1p47_AB(1.50e-05), 1zaa_C(6.09e-07), ... (total=13)
GGGCGG	PubMed	1a1h_A(1.03e-02), 1p47_AB(6.33e-07), 1zaa_C(8.73e-05), ... (total=10)
TGGGCG	PubMed	1a1h_A(3.96e-05), 1p47_AB(6.26e-07), 1zaa_C(3.61e-08), ... (total=12)

Dendrogram of similar interfaces ?

matrix format

  
  QATCNA----QAHTTT--QA--TTLAHGTCDTRG   L            +-1g2d_F    
                                           +--------1 
  --TTSGRG--LT--ETYC----NTYGQG------   L   !        +-4f6m_A    
                                         --3 
  ----------DCATSC--RGRG----SGEG--RG   L   !      +---4gzn_C    
                                           +------2 
  --------RGST--YGYC----QC--TGSTRGYT   L          +---4is1_C

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updated Thu Sep 12 14:30:55 2024