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structure nameSTRUCTURE OF THE HOMEOTIC UBX/EXD/DNA TERNARY COMPLEX
(PROTEIN HOMEOBOX PROTEIN EXTRADENTICLE)
referenceAggarwal et al. Nature 397 714 1999
sourceDROSOPHILA MELANOGASTER
experimentX-ray (resolution=2.40, R-factor=?)
structural superfamilyHomeodomain-like;
sequence familyHomeobox domain;
multimeric complexes1b8i_AB 2r5y_AB 2r5z_AB
redundant complexes2r5y_B 2r5z
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRNNR

Estimated binding specificities ?

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# IC=4.434 IC/col=0.887 n_of_columns=5 specificity:   
A |  54   0   0  96  13
C |  13   0  96   0  54
G |  16   0   0   0  13
T |  13  96   0   0  16
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: EXD
ATCAATCAAPubMed1b8i_B(2.91e-03), 1b8i_AB(3.52e-06), 2r5y_AB(1.57e-06), ... (total=5)
TGATNNATPubMed1b8i_B(1.77e-03), 1b8i_AB(2.74e-05), 2r5y_AB(1.78e-05), ... (total=5)
TGATTAATPubMed1b8i_B(1.77e-03), 1b8i_AB(2.58e-07), 2r5y_AB(1.75e-07), ... (total=5)
TGATTNATGGPubMed1b8i_B(4.06e-03), 1b8i_AB(2.55e-13), 2r5y_AB(5.83e-14), ... (total=5)
TTGATTGATPubMed1b8i_B(2.91e-03), 1b8i_AB(3.52e-06), 2r5y_AB(1.57e-06), ... (total=5)

Dendrogram of similar interfaces ?

matrix format
  
  ----------------------NT----NA--RG--   L                                 +1b8i_B    
                                                                        +--1 
  ----------------------NT----NAIARG--   L                           +--6  +1b72_B    
                                                                     !  ! 
  ----------------------NC--ITNARGRG--   L                    +------9  +--6fqq_E    
                                                              !      ! 
  ----------NT------------------------                        !      +-----7tve_F    
                                                           +-12  
  ----------------------IA--KGNA------   L                 !  !            +2hdd_A    
                                                           !  !  +---------3 
  --------------YTVC--KGDC--KC--------   L                 !  !  !         +2qhb_A    
                                                           !  +-10  
  ----------------------IA----NA------                     !     !        +4qtr_D    
                                                           !     +--------5 
  ----------------------IT--QCNAACRG--   L             +--13              +6a8r_A    
                                                       !   !  
  HTRT------------------NC--STNARG----   L             !   !              +1k61_B    
                                                       !   !          +---2 
  ----------------------NT----NAITRG--   L             !   !          !   +5zjt_B    
                                                       !   !   +------7 
  --------------------KTIA--QCNA----RT   L          +-14   !   !      !  +1ig7_A    
                                                    !  !   +--11      +--4 
  ----------------------IT--QTNAMG----   L          !  !       !         +5zjt_E    
                                                    !  !       !  
  ----------------RTQT--IT--QANAVTKTKT   L       +-15  !       +----------2ld5_A    
                                                 !  !  !  
  ------YA--------------IA--QCNAYCKG--   L       !  !  +------------------5flv_I    
                                             +--16  !  
  NGRGTG------LG--LCRG----------------       !   !  +--------------------4e9f_A    
                                             !   !  
  --------------------KGSA--QA--------   L -17   !                 +----6j5b_C    
                                             !   +-----------------8 
  --------DT----RGRCTT--KT------------   L   !                     +----2o9l_A    
                                             !  
  ----------------NTVCECSTYTSTYC------   L   +--------------------------5ed4_A    
                                           

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updated Thu Dec 22 17:22:13 2022