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structure namePURINE REPRESSOR MUTANT-HYPOXANTHINE-PURF OPERATOR COMPLEX
(PURINE NUCLEOTIDE SYNTHESIS REPRESSOR)
referenceHuffman et al. Biochemistry 41 511 2002
sourceEscherichia coli
experimentX-ray (resolution=2.50, R-factor=0.192)
structural superfamilyPeriplasmic binding protein-like I;lambda repressor-like DNA-binding domains;
sequence familyPeriplasmic binding proteins and sugar b; Bacterial regulatory proteins, lacI fami;
redundant complexes1bdh_A 1bdi_A 1jfs_A 1jh9_A 1pnr_A 1qp0_A 1qp4_A 1qp7_A 1qpz_A 1qqa_A 1qqb_A 1vpw_A 1wet_A 1zay_A 2pua_A 2pub_A 2puc_A 2pud_A 2pue_A 2puf_A 2pug_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureSTRLK

Estimated binding specificities ?

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# IC=5.339 IC/col=0.667 n_of_columns=8 specificity:   
A |   0   0   9  24  24  67   0   9
C |  96   0  67  24  24   9  96   9
G |   0  96  11  24  24  11   0  69
T |   0   0   9  24  24   9   0   9
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: PURR
GCGCAAACGTTTTCGTPubMed1jft_A(1.64e-04), 2pug_A(3.02e-07), 1jfs_A(3.03e-07), ... (total=18)
ACGCAAACGTTTGCGTPubMed1jft_A(1.64e-04), 2pug_A(3.02e-07), 1jfs_A(3.03e-07), ... (total=17)

Dendrogram of similar interfaces ?

matrix format
  
  ----SG--TC--------RG----LCKA   L                        +------1jft_A    
                                          +---------------1 
  LT----ITTGTTST----------LCRT   L   +----2               +------7ce1_D    
                                     !    ! 
  LCYCSTYGQG--STRT----HAAGLGAG   L --3    +----------------------2kej_A    
                                     ! 
  ------YTQTTTSTRAQA--HT------   L   +---------------------------1lcc_A    
                                   

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updated Tue Dec 19 05:47:34 2023