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structure nameCRYSTAL STRUCTURE OF THE JUN/CRE COMPLEX
(PROTO-ONCOGENE C-JUN)
referencePodust et al. 'To ? ? ?
sourceHomo sapiens
experimentX-ray (resolution=2.20, R-factor=0.228)
structural superfamilyA DNA-binding domain in eukaryotic transcription factors;
sequence familybZIP transcription factor; Basic region leucine zipper;
multimeric complexes1a02_FJN 1fos_EF 1fos_GH 1jnm_AB 1s9k_CDE 2h7h_AB 5t01_AB
redundant complexes2h7h 1a02 1fos 1t2k 1s9k
reference complex5t01_B
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureKNAASR

Estimated binding specificities ?

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# IC=3.520 IC/col=0.704 n_of_columns=5 specificity:   
A |  19  24   0   1  96
C |  38  24   0  76   0
G |  20  24   0  19   0
T |  19  24  96   0   0
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: jun
TGACTCAPubMed1jnm_A(3.38e-03), 1fos_EF(2.44e-08), 1fos_GH(7.05e-07), ... (total=5)
TGACGTCAPubMed1jnm_A(1.76e-05), 1jnm_AB(6.54e-13)
TGACTCAGPubMed1jnm_A(6.36e-03), 1fos_EF(1.45e-07), 1fos_GH(1.62e-06), ... (total=5)
TGCTGACGTCAGCAPubMed1jnm_A(2.62e-04), 1jnm_AB(2.36e-08)
CGCGGTGACGNTPubMed1jnm_A(1.61e-04)
TGACTGAPubMed1jnm_A(3.38e-03), 1fos_EF(2.44e-08), 1fos_GH(6.04e-03), ... (total=4)
TGCTGACTCAGCAPubMed1fos_EF(5.45e-06), 1fos_GH(1.71e-05), 2h7h_AB(1.03e-04)
CACACPubMed1s9k_CDE(1.25e-02)
TTCCACTCAPubMed1fos_GH(3.62e-06), 2h7h_AB(1.19e-02), 2h7h_A(1.02e-02)
TTACCTCAPubMed1fos_GH(1.77e-03), 1jnm_AB(5.37e-04), 2h7h_A(6.34e-03)
TGAGTAAPubMed1fos_EF(3.91e-04), 1fos_GH(7.05e-07), 1s9k_CDE(1.14e-04), ... (total=5)
CAGCTCAPubMed1fos_GH(1.01e-03), 2h7h_A(3.37e-03)
TGACATCAPubMed1jnm_A(6.36e-03), 1jnm_AB(1.15e-07), 1t2k_ABCD(2.82e-04)
TGAGTCAPubMed1jnm_A(3.38e-03), 1fos_EF(2.44e-08), 1fos_GH(7.05e-07), ... (total=5)
CGAGTCAPubMed1jnm_A(3.38e-03), 1fos_EF(5.16e-05), 1fos_GH(1.00e-03), ... (total=4)
CACCTCAPubMed1fos_GH(1.01e-03), 1jnm_AB(3.45e-03), 2h7h_A(3.37e-03)
GTGACTAAPubMed1jnm_A(6.36e-03), 1fos_EF(1.45e-07), 1fos_GH(9.74e-03), ... (total=4)
sitesourcematches (E-value)

Dendrogram of similar interfaces ?

matrix format
  
  ------RANANCATATSTRG   L       +-2e42_B    
                             +---5 
  ------RCNANCAAVT--RG   L   !   ! +1nwq_A    
                             !   +-1 
  NARTAGQTFTRG--------   L   !     +1gd2_F    
                             ! 
  --------NT--ATATSTRC   L   !       +1jnm_A    
                           --8     +-2 
  --------NCRTATATSTRG   L   !   +-4 +1t2k_D    
                             !   ! ! 
  --------NCRTATATSTRG   L   ! +-6 +1dh3_A    
                             ! ! ! 
  --------NC--AAAT--RT   L   ! ! ! +1a02_F    
                             +-7 +-3 
  --------NT--ATATSTRA   L     !   +2c9l_Y    
                               ! 
  --------NCTT--AT--RG   L     +---2dgc_A

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updated Thu Sep 12 14:46:57 2024