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structure nameHUMAN C-JUN DNA BINDING DOMAIN HOMODIMER IN COMPLEX WITH METHYLATED DNA
(Transcription factor AP-1)
referenceHorton et al. 'Nucleic 45 2503 2017
sourceHomo sapiens
experimentX-ray (resolution=1.89, R-factor=0.195)
structural superfamilyLeucine zipper domain;A DNA-binding domain in eukaryotic transcription factors;
sequence familybZIP transcription factor; Basic region leucine zipper;
multimeric complexes1a02_FJN 1fos_EF 1fos_GH 1jnm_AB 1s9k_CDE 2h7h_AB 5t01_AB
redundant complexes1a02_J 1fos_H 1jnm_A 1s9k_E 2h7h_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureNAAR

Estimated binding specificities ?

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# IC=2.341 IC/col=0.468 n_of_columns=5 specificity:   
A |  45   5   6  10  72
C |  19   6   8  62  10
G |  16  80   7  11   7
T |  16   5  75  13   7
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: jun
TGACTCAPubMed5t01_B(7.41e-07), 1fos_EF(1.21e-12), 1fos_GH(1.66e-04), ... (total=8)
TGACGTCAPubMed5t01_B(1.78e-03), 1jnm_AB(6.66e-15), 1fos_H(1.82e-03), ... (total=4)
GGTCANNNTGACCPubMed5t01_B(8.59e-03), 1fos_H(8.75e-03), 1jnm_B(8.95e-03)
TGACATCAPubMed5t01_B(1.78e-03), 1jnm_AB(5.45e-09), 1t2k_ABCD(3.80e-04), ... (total=5)
TGCTGACTCAGCAPubMed5t01_B(1.79e-05), 1fos_EF(1.86e-09), 1fos_GH(8.26e-03), ... (total=8)
GTGACTAAPubMed5t01_B(1.70e-06), 1fos_EF(2.15e-06), 2h7h_AB(4.10e-05), ... (total=6)
TTACCTCAPubMed1fos_EF(4.99e-03), 1jnm_AB(8.72e-05), 2h7h_A(6.36e-03), ... (total=4)
CGCGGTGACGNTPubMed5t01_B(7.17e-03), 1jnm_AB(6.38e-03), 1fos_H(7.30e-03), ... (total=4)
CTGACTCATPubMed5t01_B(3.79e-06), 1fos_EF(8.66e-11), 1fos_GH(1.50e-03), ... (total=8)
TGAGTAAPubMed5t01_B(6.39e-03), 1fos_EF(3.42e-07), 1fos_GH(1.66e-04), ... (total=7)
CACCTCAPubMed1fos_EF(1.09e-02), 1jnm_AB(8.95e-04), 2h7h_A(3.38e-03), ... (total=4)
TGACTGAPubMed5t01_B(7.41e-07), 1fos_EF(4.52e-07), 2h7h_AB(5.99e-06), ... (total=6)
TGCTGACGTCAGCAPubMed5t01_B(1.01e-02), 1jnm_AB(1.90e-11), 1fos_H(1.03e-02), ... (total=4)
GCAGANNNTGACCPubMed5t01_B(8.59e-03), 1fos_H(8.75e-03), 1jnm_B(8.95e-03)
TGAGTCAPubMed5t01_B(7.41e-07), 1fos_EF(1.21e-12), 1fos_GH(1.66e-04), ... (total=8)
TGACTCAGPubMed5t01_B(1.70e-06), 1fos_EF(1.45e-11), 1fos_GH(6.12e-04), ... (total=8)
CGAGTCAPubMed5t01_B(7.41e-07), 1fos_EF(2.69e-08), 2h7h_AB(5.20e-07), ... (total=7)
CAGCTCAPubMed1fos_EF(1.09e-02), 2h7h_A(3.38e-03)
sitesourcematches (E-value)

Dendrogram of similar interfaces ?

matrix format
  
  --------------RG----NC----YGATCTRG   L                    +--------2wt7_B    
                                                     +------2 
  QG----QC----FTRC------------------   L             !      +--------7aw7_D    
                                           +---------3 
  RANA----AAVT----STRG--------------   L   !         !         +----1h89_A    
                                         --4         +---------1 
  ----RA----NT----AAVT--STRG--------   L   !                   +----1hjb_A    
                                           ! 
  ------NC----AAAT----RT------------   L   +-------------------------1a02_F

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updated Fri Sep 13 20:25:48 2024