interface graph thumbnail
legend  pdf

structure nameCRYSTAL STRUCTURE OF THE DIMERIC OCT-6 (POU3F1) POU DOMAIN BOUND TO PALINDROMIC MORE DNA
(POU DOMAIN, CLASS 3, TRANSCRIPTION FACTOR 1)
referenceKolatkar et al. Proteins 79 674 2011
sourceMUS MUSCULUS
experimentX-ray (resolution=2.05, R-factor=0.198)
structural superfamilylambda repressor-like DNA-binding domains;Homeodomain-like;
sequence familyPou domain Nterminal to homeobox domain;
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureSQTCRLNRVCNQ

Estimated binding specificities ?

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# IC=6.633 IC/col=0.948 n_of_columns=7 specificity:   
A |   9  96   0   0   9  67   0
C |  67   0   0   0  67   9   0
G |  11   0   0  96  11  11   0
T |   9   0  96   0   9   9  96
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: OCT-6
ATGCAAAAPubMed2xsd_C(1.56e-03)
ATGCAAATPubMed2xsd_C(1.56e-03)
term: POU3F1
ATATGCAAPubMed2xsd_C(1.56e-03)
ATGCAAATPubMed2xsd_C(1.56e-03)
ATGCATATGCATPubMed2xsd_C(5.80e-06)

Dendrogram of similar interfaces ?

matrix format
  
  --SGQATT--RG--------   L                               +-1o4x_A    
                                   +---------------------1 
  --SGQATGCARG--------   L   +-----2                     +-8g87_X    
                             !     ! 
  ------------ITQCNAMC   L --3     +-----------------------2r5y_A    
                             ! 
  AT--QAATSA----------       +-----------------------------4z5h_A

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updated Mon Jun 29 15:47:09 2026